DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actbeta and tgfb2

DIOPT Version :9

Sequence 1:NP_651942.2 Gene:Actbeta / 43826 FlyBaseID:FBgn0024913 Length:946 Species:Drosophila melanogaster
Sequence 2:XP_002936067.1 Gene:tgfb2 / 100489680 XenbaseID:XB-GENE-480560 Length:411 Species:Xenopus tropicalis


Alignment Length:456 Identity:106/456 - (23%)
Similarity:179/456 - (39%) Gaps:126/456 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   536 RKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHD--KNRYH 598
            :::..|.|..:::  ||.::.|.|.          .:.||:|.:....:|    .|.|  :.:.:
 Frog    35 KRIEAIRGQILSK--LKLNSPPEDY----------PEPGEVSQDVIAIYN----STRDLLQEKAN 83

  Fly   599 EGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFS 663
            |..:|.           |.::...|.:|.:...||...::  |.|.:......|.|  :||:.|.
 Frog    84 ERAASC-----------ERERSEDEYYAKEVYKIDMLPYY--TSENVIPPSYTTPY--FRIVRFD 133

  Fly   664 AQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLS 728
            ..:    .:|.:....:...|:.:                |:|.|    |.....||::  :|:.
 Frog   134 VSS----MEKNASNLVKAEFRVFR----------------LMNPK----ARVSEQRIEL--YQIL 172

  Fly   729 TSINI---TEKGID-KAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGG 789
            .|.::   |::.|| |.:..||..:       |..||:|:.|.||.    |.|.|.|      |.
 Frog   173 KSKDLASPTQRYIDSKVVKTRAEGE-------WLSFDVTEAINEWL----HHKDRNL------GF 220

  Fly   790 RYSLH------LFQTSKLRGNSSDYLST-------------NP----------NRPFLVL----- 820
            :.|||      :...:.:..|.|:.|.|             :|          ..|.|:|     
 Frog   221 KISLHCPCCTFIPSNNYIIPNKSEELETRFAGIDDAYMYAGDPKTKSRKKHTGRTPHLLLMLLPS 285

  Fly   821 -HTESSRTRRVRRRAVD---CGGALNGQCCKESFYVSFKA-LGWDDWIIAPRGYFANYCRGDCTG 880
             ..||.::.|.::||:|   |...:...||....|:.||. ||| .||..|:||.||:|.|.|..
 Frog   286 YRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPY 349

  Fly   881 SFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECG 944
            .:.:    .|.|:..:..|..:.......|||......|::::|| |:...|:: |..|:|..|.
 Frog   350 LWSS----DTQHSRVLSLYNTINPEASASPCCVSQDLDSLTILYYIGNKPKIEQ-LSNMIVKSCK 409

  Fly   945 C 945
            |
 Frog   410 C 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActbetaNP_651942.2 TGFb_propeptide 370..>509 CDD:279078
TGF_beta 843..945 CDD:278448 33/103 (32%)
tgfb2XP_002936067.1 TGFb_propeptide 21..228 CDD:366248 57/266 (21%)
TGF_beta_TGFB2 314..410 CDD:381655 33/101 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11848
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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