DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and gdf5

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001128589.1	Gene:	gdf5 / 100189547	XenbaseID:	XB-GENE-481784	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	84/345 - (24%)
Similarity:	129/345 - (37%)	Gaps:	82/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 GNTQEIITFAEEG------TQYRQYRILEFSA--QNRRVPSQKLSIRSAQIHIRIDKPHSLWIEK 695
            |....|.:|.::|      ...||....:.||  ::..:.::...:|...|..:::....||..|
Frog   195 GLANTITSFIDKGQDERMAAARRQKYTFDISALEKDGLLGAELRILRKRPIDAKLNSAGKLWQIK 259

  Fly   696 AKSLPEKH----LLNTKRKWGANKPHHRI-KIWVF--------QLSTSINITEKGIDKAIIFRAS 747
            ..|.|...    ||:::.....:.|...: .||..        ||...:.:.:||
Frog   260 LYSCPANKKSATLLDSRPLGSIDTPKWEVFDIWKLYKNFKNSVQLCFELEVLDKG---------- 314

  Fly   748 FQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLH--LFQTSKLRGNSSD--- 807
               .|.:|....|:.|       |..::||...|:     .||....  .|...|.|....|
Frog   315 ---KPADLRSVGFNRT-------GRQTNEKAIFLV-----FGRTKKRDLFFNEIKARSGQDDKTV 364

  Fly   808 --YLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYF 870
              ||.....:....|.|...:......:|         :|.|:..:|:||.:|||||||||..|.
Frog   365 YEYLFNQRRKRRAPLSTRQGKRPNKNSKA---------RCSKKPLHVNFKDMGWDDWIIAPLEYE 420

  Fly   871 ANYCRGDCTGSFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYG 926
            |.:|.|.|....|:   |    |.||..      ..|||.|.|      ||.|.:.|.:|::|..
Frog   421 AYHCEGLCEFPLRSHLEP----TNHAVI------QTLMNSMDPETTPPTCCVPTRLSPISILYTD 475

  Fly   927 D-DGIIKRDLPKMVVDECGC 945
            . :.::.:....|||:.|||
Frog   476 SANNVVYKQYEDMVVESCGC 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	39/111 (35%)
gdf5	NP_001128589.1	TGFb_propeptide	142..328	CDD:279078	28/152 (18%)
gdf5	NP_001128589.1	TGFB	395..496	CDD:214556	41/111 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910