DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and bmp6

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001106378.1	Gene:	bmp6 / 100127176	XenbaseID:	XB-GENE-479134	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	515	Identity:	112/515 - (21%)
Similarity:	195/515 - (37%)	Gaps:	160/515 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 IDKKNSFLNGWTENRQLKINSQIASMPIELKSHH-NSSPKELKS-----GAVRKVNGINGTQMNE 548
            :||::|..:|:...|              ||||. ....||:.|     ...|.::|::.:|:|:
Frog    27 VDKRSSMDSGFLYRR--------------LKSHEKREMQKEILSILGLPHRPRPIHGLSPSQLNQ 77

  Fly   549 NALKKST--YPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIH 611
            .....|.  :.:|:.:::     :|::..|...|:.:          :...|.           |
Frog    78 PGKLNSAPLFMLDLYNAM-----SGQDQGMDLKDWSH----------RATLHS-----------H 116

  Fly   612 NIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFA-----EEGTQYRQYRILEFSAQNRRVPS 671
            .::.::..|.|...|.|      ..|..:...:::|.     ::....|.:...|:.....::|.
Frog   117 QLKVKSLLGSHLGSAQD------SAFLSDADMVMSFVNLVEHDKDLSPRLWHHKEYKFNLSQIPE 175

  Fly   672 QKLSIRSAQIHIRID------KPHSLWIEKAKSLPEKH-------LLNTKRKWGANKPHHRIKIW 723
            .: ::.:|:..|..|      :..:..|...:.|.|..       ||:|:..|.:::
Frog   176 GE-AVTAAEFRIYKDCVLGSFENQTFLISIYQVLAEHRNRETNIFLLDTQTVWASDE-------- 231

  Fly   724 VFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHE-KLRLLID---- 783
                                            ||.:||:|.|...|..:..|. .|:|.::
Frog   232 --------------------------------GWLEFDITATSNLWVMNPRHNFGLQLRVETRDG 264

  Fly   784 ------CTGCGGR--------YSLHLFQTSKL-----RGNSSDYLSTNPNRPFLVLHTESSRTRR 829
                  ..|..||        :.:..|:.|::     |..:|...:.|.||     :|::....|
Frog   265 RNINAKAAGLVGRDGPYDKQPFMVAFFKASEVHLRTTRSATSKRKNQNRNR-----YTQAQDVSR 324

  Fly   830 VRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAH 894
            |..........|...|.|...||||:.|||.||||||:||.||||.|:|  ||       ..:||
Frog   325 VSSITDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCGGEC--SF-------PLNAH 380

  Fly   895 FIEEYRK-----MGLMNG---MRPCCAPIKFSSMSLIYYGDD-GIIKRDLPKMVVDECGC 945
            .......     :.|||.   .:|||||.|.:::|::|:.|: .:|.:....|||..|||
Frog   381 MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078	5/18 (28%)
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	44/110 (40%)
bmp6	NP_001106378.1	TGFb_propeptide	32..290	CDD:366248	53/344 (15%)
bmp6	NP_001106378.1	TGF_beta_BMP6	339..441	CDD:381666	46/111 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910