Protein Alignment sv and PHOX2B

DIOPT Version :10

• Sequence 1: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 69/339 - (20%)
• Similarity: 98/339 - (28%)
• Gaps: 116/339 - (34%)

  Fly   527 SGNDTSML---YDSITTISQTQSSIYTP---AIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTV 585
            :|.|||.|   |...::.||.....|.|   ..|.:.|..||||        ...|..::::...
Human    19 AGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTP--------GSCSLGTLRDHQS 75

  Fly   586 PPF----YTALAFDGNY----------TSMTS--LENCSSLVGQEHIVMPESSDSNTLCPISTRI 634
            .|:    |......|..          |:.||  |:....:..:.|.     .|..|...::.:|
Human    76 SPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHY-----PDIYTREELALKI 135

  Fly   635 VPDITETN----------STRVKEPLTNSDGCSEDNNKEPEKSNSSQSSDHIASPHLHHIGEEQL 689
              |:||..          ..|.:|....:...:..|....:||:||:..:
Human   136 --DLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDE--------------- 183

  Fly   690 RGNRRSNLNASTHPSSLIPLQPSGGSSLLNINPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSA 754
                 |....||.|.|      :||       |..|                 |...||......
Human   184 -----SKEAKSTDPDS------TGG-------PGPN-----------------PNPTPSCGANGG 213

  Fly   755 GCSSVVP-GSDYAYNPAYTQYGGAYGSYGYGTGSGLINSSYYYESGQTQSPLTHDLRSPLVATRA 818
            |.....| |:..|..|     ||..|..|.|             .....:.......:...|..|
Human   214 GGGGPSPAGAPGAAGP-----GGPGGEPGKG-------------GAAAAAAAAAAAAAAAAAAAA 260

  Fly   819 NSLASAASPGSGSA 832
            ..||:|..||.|.|
Human   261 GGLAAAGGPGQGWA 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645
PHOX2B	NP_003915.2	Homeodomain	99..155	CDD:459649	11/62 (18%)
		polyalanine repeat	241..260		1/18 (6%)