DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sv and Pax8

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_112403.2	Gene:	Pax8 / 81819	RGDID:	620434	Length:	457	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	210/685 - (30%)
Similarity:	270/685 - (39%)	Gaps:	258/685 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 HSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILS 229
            |:|..|    ||||:|||||.||||||||:|||||||:|||.||||||||||||||||||||||.
  Rat     3 HNSIRS----GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG 63

  Fly   230 RYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSI 294
            |||||||.:.|||||||||||||.||:.|.:|||:||||||||||||||||.:|..|.|||||||
  Rat    64 RYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI 128

  Fly   295 NRIVRNKAAEKAKHVHHHQQHH--------VSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSAN 351
            |||:|.|.          ||..        .::||..||....|     ..:..|:.|.|:|
  Rat   129 NRIIRTKV----------QQPFNLPMDSCVATKSLSPGHTLIPS-----SAVTPPESPQSDS--- 175

  Fly   352 SVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGI-QHGH 415
                                                    :.||       |||||:||| |.|
  Rat   176 ----------------------------------------LGST-------YSINGLLGIAQPG- 192

  Fly   416 HSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHS-DNDDGKRQRMSTYSGDQLYTNIWSG 479
                              |..|||..::..::...:|.| .:..|.|:.:.|.:..|
  Rat   193 ------------------SDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDTFGQ-------- 231

  Fly   480 KWCIKDDHKLLAELGNLTASTGNCP---ATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTI 541
                   |.|         ....||   ..|.||                        |.|.:..
  Rat   232 -------HHL---------EPLECPFERQHYPEA------------------------YASPSHT 256

  Fly   542 SQTQSSIYTPAIGPSI--GTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMTSL 604
            ...|.....|.:..::  |..:|||      ....|..|....||.|
  Rat   257 KGEQGLYPLPLLNSTLDDGKATLTP------SNTPLGRNLSTHQTYP------------------ 297

  Fly   605 ENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNS 669
                 :|...|  .|.:....|         |:::.::||                   |...:|
  Rat   298 -----VVADPH--SPYAIKQET---------PELSSSSST-------------------PSSLSS 327

  Fly   670 SQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSG---GSSLLN----INPSENRS 727
            |...|      |..:|.....|......||.:|.:|:.     |   |.:||:    :.|:
  Rat   328 SAFLD------LQQVGSGGPAGASVPPFNAFSHAASVY-----GQFTGQALLSGREMVGPT---- 377

  Fly   728 DVELNLSNNVGLYSTPTVLPSF---NHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYG---TG 786
                       |...|..:|:.   ::.|:..:.:|.||:|:.| ||:.  ..|.||...   ..
  Rat   378 -----------LPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGN-AYSH--TPYASYSEAWRFPN 428

  Fly   787 SGLINSSYYYESGQTQSPLTHDLRSPLVATRANSL 821
            |.|::|.|||.|      .|.....|..||..:.|
  Rat   429 SSLLSSPYYYSS------TTRPSAPPTSATAFDHL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	103/123 (84%)
Pax8	NP_112403.2	PAX	9..133	CDD:128645	103/123 (84%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		49/55 (89%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		35/47 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..226		25/140 (18%)
		Pax2_C	344..455	CDD:289189	34/139 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2386
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I2979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45707
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970