DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sv and pax8

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_001339893.5	Gene:	pax8 / 60637	ZFINID:	ZDB-GENE-001030-3	Length:	448	Species:	Danio rerio

Alignment Length:	646	Identity:	199/646 - (30%)
Similarity:	267/646 - (41%)	Gaps:	223/646 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGS 236
            :|.||||:|||||:||||||||:|:|||||::||.||||||||||||||||||||||.|||||||
Zfish     5 TGRGHGGLNQLGGMFVNGRPLPEVIRQRIVDMAHQGVRPCDISRQLRVSHGCVSKILGRYYETGS 69

  Fly   237 FKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNK 301
            .|.|||||||||||||.||:.||.|||:||||||||||||||||.:|..|.||||||||||:|.|
Zfish    70 IKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAEGVCDGDTVPSVSSINRIIRTK 134

  Fly   302 AAEKAKHVHHHQQHHV---SQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASV 363
            .         .|..::   ::.|..||....|     ..:..|:.|.|:|
Zfish   135 V---------QQPFNLPLDTKGLSPGHTLIPS-----SAVTPPESPQSDS--------------- 170

  Fly   364 HASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQH----GHHSHNNNNNS 424
                                        :.||       |||||:|||..    |...|::::..
Zfish   171 ----------------------------LGST-------YSINGLLGITQTTADGKRGHDDSDQE 200

  Fly   425 SVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMSTYSGDQLYTNIWSGKWCIKDDHKL 489
            |..::.:::.|                     ..|.|:::.|                   :|..
Zfish   201 SCRHSVDSQGS---------------------GGGARKQLRT-------------------EHFP 225

  Fly   490 LAELGNLTASTGNCPATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSIYTPAI- 553
            .|.|        :|....:.:|:.||.                         |:.:..:|..|:
Zfish   226 SAAL--------DCGFERHYSSDSFSQ-------------------------SKAEQQLYPLALM 257

  Fly   554 GPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMT-SLENCSSLVGQEHIV 617
            .|.:..|.              .|:||...        ||....|..:| :|:.....:.||  |
Zfish   258 NPGLDEGK--------------GASSISRN--------LAAHQGYAVVTEALQPLPLCLKQE--V 298

  Fly   618 MPESSDSNTLCP----ISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNSSQSSDHIAS 678
            .||   .|:|.|    ||.....|::..:|.. ..|:.:|.|.:       ..|:...|..|.|.
Zfish   299 SPE---VNSLSPSPHIISGSAFLDLSAISSPS-SAPVASSCGSA-------HLSHGFSSFSHHAP 352

  Fly   679 PHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSGGSSLLNINPSENRSDVELNLSNNVGLYSTP 743
            .|........:.|...::.....:|.. ||...:|.||                 |...|:.|.|
Zfish   353 VHGQFSSPSLMAGREVASSMLPGYPPH-IPTAQTGFSS-----------------STIAGMVSAP 399

  Fly   744 TVLPSFNHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYGTGSGLINSSYYYESGQTQSP 804
                   .|:        |..|:: |||:.|..|:..    |.|.::.|.|||.|.....|
Zfish   400 -------EYT--------GQSYSH-PAYSSYSEAWRF----TNSSILGSPYYYSSATRPPP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	103/123 (84%)
pax8	XP_001339893.5	PAX	8..132	CDD:128645	103/123 (84%)
pax8	XP_001339893.5	Pax2_C	343..437	CDD:289189	30/131 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2381
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3035
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.930