Protein Alignment sv and PAX9

DIOPT Version :10

• Sequence 1: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_006185.1
• Gene: PAX9 / 5083
• HGNCID: 8623
• Length: 341
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 121/268 - (45%)
• Similarity: 153/268 - (57%)
• Gaps: 55/268 - (20%)

  Fly   177 GGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGV 241
            |.|||||||||||||||:.:|.||||||..|:||||||||||||||||||||:||.||||...|.
Human     6 GEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGA 70

  Fly   242 IGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNKAAEKA 306
            ||||||:|.||.||..|..||:.:|.:|||||||||||:.:|.:.||||||||:||:|||....|
Human    71 IGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLA 135

  Fly   307 KHVHH--HQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASVHASIPT 369
            :..|:  ::||..:                      |||....:...|..:.::|:|   |.:||
Human   136 QQGHYDSYKQHQPT----------------------PQPALPYNHIYSYPSPITAAA---AKVPT 175

  Fly   370 -SGTDSVQVSVGHINANSNETTHINSTAEQRT--TGYSINGILGIQ---------HGHHSHNNNN 422
             .|..::..||                |..||  :.:|:..||||:         ..:||.....
Human   176 PPGVPAIPGSV----------------AMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEE 224

  Fly   423 NSSVNNNN 430
            .||:..||
Human   225 WSSLGRNN 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	88/121 (73%)
PAX9	NP_006185.1	PAX	6..131	CDD:238076	90/124 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	7..63		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	82..130		29/47 (62%)
		Interaction with KDM5B. /evidence=ECO:0000269|PubMed:12657635	168..189		9/39 (23%)