DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sv and PAX5

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	471	Identity:	186/471 - (39%)
Similarity:	218/471 - (46%)	Gaps:	151/471 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGS 236
            |..|||||||||||||||||||||||||||||||.||||||||||||||||||||||.|||||||
Human    13 SRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGS 77

  Fly   237 FKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNK 301
            .|.|||||||||||||.||:.||.|||:||||||||||||||||.:|..|.||||||||||:|.|
Human    78 IKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTK 142

  Fly   302 AAEKAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASVHAS 366
            .                                      .|||           |....||.|:.
Human   143 V--------------------------------------QQPP-----------NQPVPASSHSI 158

  Fly   367 IPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNN 431
            :.|.....|. ||...:|.|:               |||:|||||          .:.|.:.|
Human   159 VSTGSVTQVS-SVSTDSAGSS---------------YSISGILGI----------TSPSADTN-- 195

  Fly   432 TESSCKRKRIEAHDENHDTNIHS-DNDDGKRQRMSTYSGD----------------QLYTNIWSG 479
                 ||||.|...|:...|.|| ...|..|::|   .||                |.|::|::.
Human   196 -----KRKRDEGIQESPVPNGHSLPGRDFLRKQM---RGDLFTQQQLEVLDRVFERQHYSDIFTT 252

  Fly   480 KWCIK----DDHKLLAEL--------GNLTASTGNCPATYYEASNGFSTTPISGSGATASGNDTS 532
            ...||    .::..:|.|        .||.:.|   ||....:..|..:.||      .:|.|
Human   253 TEPIKPEQTTEYSAMASLAGGLDDMKANLASPT---PADIGSSVPGPQSYPI------VTGRD-- 306

  Fly   533 MLYDSITTISQTQSSIYTPAIGPSIGTGS-----LTPLVPIS-------MHEMKLSANSIQEQTV 585
                    ::.|....|.|.:.|: |.||     ||.:||.|       .|....|.|.......
Human   307 --------LASTTLPGYPPHVPPA-GQGSYSAPTLTGMVPGSEFSGSPYSHPQYSSYNDSWRFPN 362

  Fly   586 P-----PFYTALAFDG 596
            |     |:|.:.|..|
Human   363 PGLLGSPYYYSAAARG 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	109/123 (89%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		5/7 (71%)
		PAX	16..140	CDD:128645	109/123 (89%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		53/55 (96%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		36/47 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		16/52 (31%)
		Pax2_C	279..389	CDD:403565	30/120 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2439
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3058
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41583
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5005
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.960