DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sv and PAX2

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_003981.3	Gene:	PAX2 / 5076	HGNCID:	8616	Length:	432	Species:	Homo sapiens

Alignment Length:	477	Identity:	186/477 - (38%)
Similarity:	220/477 - (46%)	Gaps:	147/477 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 DSHSSQGSISG--DGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVS 225
            |.|......|.  .|||||||||||||||||||||||||||||||.|||||||||||||||||||
Human     2 DMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVS 66

  Fly   226 KILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPS 290
            |||.|||||||.|.|||||||||||||.|||.||.|||:||||||||||||||||.||..|.|||
Human    67 KILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPS 131

  Fly   291 VSSINRIVRNKAAEKAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNT 355
            |||||||:|.|                                    :.:|..||.:.:...|
Human   132 VSSINRIIRTK------------------------------------VQQPFHPTPDGAGTGV-- 158

  Fly   356 NVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNN 420
                :|..|..:|::.:..|                 :|.:......|||||||||.
Human   159 ----TAPGHTIVPSTASPPV-----------------SSASNDPVGSYSINGILGIP-------- 194

  Fly   421 NNNSSVNNNNNTESSCKRKRIE-------AH--------------DENHDTNIHSDNDDG----- 459
                    .:|.|   ||||.|       ||              |.:..:..:.|:..|
Human   195 --------RSNGE---KRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLR 248

  Fly   460 KRQRMSTYSGDQL-----------YTNIWSGKWCIKDDHKLLAELGN---LTASTGNCPATYYEA 510
            |..|..|::..||           |.:::.....||      :|.||   |.|.|......  ::
Human   249 KHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIK------SEQGNEYSLPALTPGLDEV--KS 305

  Fly   511 SNGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSI--YTPAIGP----SIGTGSLTPLVPIS 569
            |...||.|..||  ..||..|   |..:|......:::  |.|.:.|    |..|.:|..:||.|
Human   306 SLSASTNPELGS--NVSGTQT---YPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGS 365

  Fly   570 MHEMKLSANSIQEQTVPPFYTA 591
                :.|.|....    |.|||
Human   366 ----EFSGNPYSH----PQYTA 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	111/123 (90%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	111/123 (90%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		53/55 (96%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		38/47 (81%)
		homeodomain	255..>278	CDD:412151	4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..325		9/25 (36%)
		Pax2_C	305..>390	CDD:403565	26/88 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2439
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3058
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41583
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.930