Protein Alignment sv and OTX1

DIOPT Version :10

• Sequence 1: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 58/275 - (21%)
• Similarity: 95/275 - (34%)
• Gaps: 68/275 - (24%)

  Fly   516 TTPI-SGSGATASGNDT-SMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSAN 578
            ::|: ..||:.:||..| ..:..|.::.|...||...||...:.|.|. .|:...|......:::
Human   112 SSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGG-NPVAAASSLSTPAASS 175

  Fly   579 SIQEQTVPPFYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNS 643
            .....::.|        |:..:..|:..            |.::.|||.|...:......|...|
Human   176 IWSPASISP--------GSAPASVSVPE------------PLAAPSNTSCMQRSVAAGAATAAAS 220

  Fly   644 TRVKEPLTNSDGCSEDNNKEPEKSNS----SQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPS 704
                .|::...|.|.... .|..|:|    ...|.::|..|.||                  ||.
Human   221 ----YPMSYGQGGSYGQG-YPTPSSSYFGGVDCSSYLAPMHSHH------------------HPH 262

  Fly   705 SLIPLQPSGGSSLLNINPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSAGCSSVVPGSDYAYNP 769
            .|.|:.||..:...:.:|..:..     ||.:.|.:.     ...:|:..|..    ||..|:|.
Human   263 QLSPMAPSSMAGHHHHHPHAHHP-----LSQSSGHHH-----HHHHHHHQGYG----GSGLAFNS 313

  Fly   770 A----YTQYGGAYGS 780
            |    |.:.|.|..|
Human   314 ADCLDYKEPGAAAAS 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		9/33 (27%)
		TF_Otx	178..274	CDD:427350	27/138 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		14/75 (19%)