DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sv and Arx

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	123/672 - (18%)
Similarity:	219/672 - (32%)	Gaps:	197/672 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 SRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSS 293
            ::|.|.|..:........|.:.:...:|:|..  |.:|      .:.|||..|    .::|:..:
  Rat     3 NQYQEEGCSERPECKSKSPTLLSSYCIDSILG--RRSP------CKMRLLGAA----QSLPAPLA 55

  Fly   294 INRIVRNKAAE---KAKHVHHHQQHHVSQSL------GGGHI-------------ATESVDSSTG 336
             :|..:.||.:   |........:.|:...|      |||.:             |..:..::||
  Rat    56 -SRTDQEKAMQGSPKGSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATG 119

  Fly   337 TIG------EPQPPTSNSSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINST 395
            |.|      .|.||.:.......:....|:|:..|......:.:.|||:
  Rat   120 TAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKISQAPQVSI---------------- 168

  Fly   396 AEQRTTGYSINGI-----------LGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHD 449
              .|:..|..||.           || ..|..:|.....|:.:...:..::......|   |:.:
  Rat   169 --SRSKSYRENGAPFVPPPPALDELG-GPGGVAHPEERLSAASGPGSAPAAGGGTGTE---EDEE 227

  Fly   450 TNIHSDNDDGKRQRMSTYSGDQLYTNIWSGKWCIKDDHK-LLAELGNLT-ASTGNCPATYYEASN 512
            ..:..:.|:.:.:.:.....::|          ::||.: ||.|....: |:||...|.   |:.
  Rat   228 ELLEDEEDEDEEEELLEDDEEEL----------LEDDARALLKEPRRCSVATTGTVAAA---AAA 279

  Fly   513 GFSTTPISGSGATASGNDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSA 577
            ..:...::..|...|..:..:|:.........:.|:..     |.|:.|...|:.......:.:.
  Rat   280 AAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCL-----SAGSDSEEGLLKRKQRRYRTTF 339

  Fly   578 NSIQEQTVPPFYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETN 642
            .|.|.:.:...:....:...:|             :|.:.|              |:  |:||
  Rat   340 TSYQLEELERAFQKTHYPDVFT-------------REELAM--------------RL--DLTE-- 373

  Fly   643 STRVKEPLTNSDGCSEDNNKEPEKSNSSQ-----------SSDHIASPHL-------HHIGEEQL 689
             .||:....|    .....::.||:.:..           |:.|..||:|       ||...:.
  Rat   374 -ARVQVWFQN----RRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDS- 432

  Fly   690 RGNRRSNLNASTHPSSLIPLQPSGGSSLLNINPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSA 754
            .....:...|:..||    |.|..||:.|   |.   |...|.||..:|       ...|.|
  Rat   433 AWTAAAAAAAAAFPS----LPPPPGSASL---PP---SGAPLGLSTFLG-------AAVFRH--- 477

  Fly   755 GCSSVVPGSDYAYNPAYTQYGGAYGSYGYGTGSGLINSSYYYESGQTQSPLTHDLRSPLVATRAN 819
                          ||:  ...|:|.. :.|.:.|.::|       |.:.|   ||.|..|.. .
  Rat   478 --------------PAF--ISPAFGRL-FSTMAPLTSAS-------TAAAL---LRQPTPAVE-G 514

  Fly   820 SLASAASPGSGSACTKSESSDI 841
            ::||.|.....:|.....:|.|
  Rat   515 AVASGALADPATAAADRRASSI 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	14/69 (20%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		30/176 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		4/37 (11%)
		Homeobox	336..388	CDD:278475	12/87 (14%)
		OAR	530..547	CDD:281777	2/7 (29%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910