Protein Alignment sv and pax6a

DIOPT Version :10

• Sequence 1: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_009296153.1
• Gene: pax6a / 30567
• ZFINID: ZDB-GENE-990415-200
• Length: 459
• Species: Danio rerio
• Alignment Length: 593
• Identity: 175/593 - (29%)
• Similarity: 245/593 - (41%)
• Gaps: 202/593 - (34%)

  Fly   157 IQNGAEDSHSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLR--- 218
            :||...|       |..:||.|||||||||||||||||..||:||||||:|.|||||||.|:
Zfish    20 MQNKVYD-------ICNEGHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHA 77

  Fly   219 -----------VSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWE 272
                       ||:|||||||.|||||||.:...||||||:||||.||..||.||||.|::||||
Zfish    78 DAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWE 142

  Fly   273 IRDRLLAEAICSQDNVPSVSSINRIVRNKAAEKAKHVHHHQQHHVSQSLG--GGHIATESVDSST 335
            ||||||:|.:|:.||:||||||||::||.|:||             |.:|  |.:.....::..|
Zfish   143 IRDRLLSEGVCTNDNIPSVSSINRVLRNLASEK-------------QQMGADGMYEKLRMLNGQT 194

  Fly   336 GTIGE----------PQPPTSN----SSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANS 386
            ||.|.          |..|..:    |.....|||         ||.::|.||
Zfish   195 GTWGTRPGWYPGTSVPGQPNQDGCQQSDGGGENTN---------SISSNGEDS------------ 238

  Fly   387 NETTHINSTAEQRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTN 451
             :.|.:....:::.                           ..|.|  |..:::|||.::..:..
Zfish   239 -DETQMRLQLKRKL---------------------------QRNRT--SFTQEQIEALEKEFERT 273

  Fly   452 IHSDNDDGKRQRMST-YSGDQLYTNIW----SGKWCIKDDHKLLAELGNLTASTGNCPATYYEAS 511
            .:.  |...|:|::. ....:....:|    ..||  :.:.||..:              ..:||
Zfish   274 HYP--DVFARERLAAKIDLPEARIQVWFSNRRAKW--RREEKLRNQ--------------RRQAS 320

  Fly   512 NGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLS 576
            |..|..|||.|.:|                     |:|.|
Zfish   321 NSSSHIPISSSFST---------------------SVYQP------------------------- 339

  Fly   577 ANSIQEQTVPPFYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITET 641
               |.:.|.|..:|:.:..|.  |.|:|.|..|                .|.|     :|..|..
Zfish   340 ---IPQPTTPVSFTSGSMLGR--SDTALTNTYS----------------ALPP-----MPSFTMA 378

  Fly   642 NSTRVKEPLTNSDGCSEDNNKEPEKSNSSQSSDHIASPHLH-HIGEEQLRGNRRSNLNASTHPSS 705
            |:..::...|:|..|....:    .|.:.:|.|....||:. |:..:.:..:..::....: |..
Zfish   379 NNLPMQPSQTSSYSCMLPTS----PSVNGRSYDTYTPPHMQAHMNSQSMAASGTTSTGLIS-PGV 438

  Fly   706 LIPLQPSG 713
            .:|:|..|
Zfish   439 SVPVQVPG 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	93/137 (68%)
pax6a	XP_009296153.1	PAX	31..169	CDD:128645	93/137 (68%)
		Homeodomain	253..308	CDD:459649	12/60 (20%)