DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sv and Pax8

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_035170.1	Gene:	Pax8 / 18510	MGIID:	97492	Length:	457	Species:	Mus musculus

Alignment Length:	665	Identity:	207/665 - (31%)
Similarity:	268/665 - (40%)	Gaps:	248/665 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 HSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILS 229
            |:|..|    ||||:|||||.||||||||:|||||||:|||.||||||||||||||||||||||.
Mouse     3 HNSIRS----GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG 63

  Fly   230 RYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSI 294
            |||||||.:.|||||||||||||.||:.|.:|||:||||||||||||||||.:|..|.|||||||
Mouse    64 RYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI 128

  Fly   295 NRIVRNKAAEKAKHVHHHQQHH--------VSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSAN 351
            |||:|.|.          ||..        .::||..||....|     ..:..|:.|.|:|
Mouse   129 NRIIRTKV----------QQPFNLPMDSCVATKSLSPGHTLIPS-----SAVTPPESPQSDS--- 175

  Fly   352 SVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGI-QHGH 415
                                                    :.||       |||||:||| |.|
Mouse   176 ----------------------------------------LGST-------YSINGLLGIAQPG- 192

  Fly   416 HSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMSTYSGDQLYTNIWSGK 480
                |:|...:::::  :.|| |..|::..        |.:...|..|..|:|
Mouse   193 ----NDNKRKMDDSD--QDSC-RLSIDSQS--------SSSGPRKHLRTDTFS------------ 230

  Fly   481 WCIKDDHKLLAELGNLTASTGNCP---ATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTIS 542
                 .|.|.|.         .||   ..|.||                        |.|.:...
Mouse   231 -----QHHLEAL---------ECPFERQHYPEA------------------------YASPSHTK 257

  Fly   543 QTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMTSLENC 607
            ..|.....|.:..::..|..|    ::.....|..|....||.|
Mouse   258 GEQGLYPLPLLNSALDDGKAT----LTSSNTPLGRNLSTHQTYP--------------------- 297

  Fly   608 SSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNSSQS 672
              :|...|  .|.:....|         |:::.::||                   |...:||..
Mouse   298 --VVADPH--SPFAIKQET---------PELSSSSST-------------------PSSLSSSAF 330

  Fly   673 SDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSG---GSSLLN----INPSENRSDVE 730
            .|      |..:|.....|......||..|.:|:.     |   |.:||:    :.|:
Mouse   331 LD------LQQVGSGGPAGASVPPFNAFPHAASVY-----GQFTGQALLSGREMVGPT------- 377

  Fly   731 LNLSNNVGLYSTPTVLPSF---NHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYG---TGSGL 789
                    |...|..:|:.   ::.|:..:.:|.||:|:.| ||:.  ..|.||...   ..|.|
Mouse   378 --------LPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGN-AYSH--TPYSSYSEAWRFPNSSL 431

  Fly   790 INSSYYYESGQTQSP 804
            ::|.|||.|  |..|
Mouse   432 LSSPYYYSS--TSRP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	103/123 (84%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	103/123 (84%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		49/55 (89%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		35/47 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..224		25/135 (19%)
		Pax2_C	344..455	CDD:372091	32/126 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2462
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3038
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43631
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.920