Protein Alignment sv and Pax6

DIOPT Version :10

• Sequence 1: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_038655.1
• Gene: Pax6 / 18508
• MGIID: 97490
• Length: 436
• Species: Mus musculus
• Alignment Length: 639
• Identity: 176/639 - (27%)
• Similarity: 249/639 - (38%)
• Gaps: 248/639 - (38%)

  Fly   174 DGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLR--------------VSHGCV 224
            :.|.|||||||||||||||||..||:||||||:|.|||||||.|:              ||:|||
Mouse     3 NSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHADAKVQVLDNENVSNGCV 67

  Fly   225 SKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVP 289
            ||||.|||||||.:...||||||:||||.||..||.||||.|::||||||||||:|.:|:.||:|
Mouse    68 SKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIP 132

  Fly   290 SVSSINRIVRNKAAEKAKHVHHHQQHHVSQSLG--GGHIATESVDSSTGTIGE----------PQ 342
            |||||||::||.|:||             |.:|  |.:.....::..||:.|.          |.
Mouse   133 SVSSINRVLRNLASEK-------------QQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPG 184

  Fly   343 PPTSN----SSANSVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGY 403
            .||.:    ......|||         ||.::|.||.:..:         ...:....::..|.:
Mouse   185 QPTQDGCQQQEGGGENTN---------SISSNGEDSDEAQM---------RLQLKRKLQRNRTSF 231

  Fly   404 SINGILGIQHGHHSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMST-Y 467
            :                                 :::|||.::..:...:.  |...|:|::. .
Mouse   232 T---------------------------------QEQIEALEKEFERTHYP--DVFARERLAAKI 261

  Fly   468 SGDQLYTNIW----SGKWCIKDDHKLLAELGNLTASTGNCPATYYEASNGFSTTPISGSGATASG 528
            ...:....:|    ..||  :.:.||..:              ..:|||..|..|||.|.:|
Mouse   262 DLPEARIQVWFSNRRAKW--RREEKLRNQ--------------RRQASNTPSHIPISSSFST--- 307

  Fly   529 NDTSMLYDSITTISQTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALA 593
                              |:|.|.  |.       |..|:|
Mouse   308 ------------------SVYQPI--PQ-------PTTPVS------------------------ 321

  Fly   594 FDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPL---TNSDG 655
               ::||.:.|....:.:...:..:|.              :|..|..|:..::.|:   |:|..
Mouse   322 ---SFTSGSMLGRTDTALTNTYSALPP--------------MPSFTMANNLPMQPPVPSQTSSYS 369

  Fly   656 CSEDNNKEPEKSNSSQSSDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSGGSSLLNI 720
            |....:    .|.:.:|.|....||:                  .||.:|    ||.|.|.
Mouse   370 CMLPTS----PSVNGRSYDTYTPPHM------------------QTHMNS----QPMGTSG---- 404

  Fly   721 NPSENRSDVELNLSNNVGLYSTPTVLPSFNHYSAGCSSVVPGSDYAYNPAYTQY 774
                         :.:.||.|....:|          ..||||:    |..:||
Mouse   405 -------------TTSTGLISPGVSVP----------VQVPGSE----PDMSQY 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	92/137 (67%)
Pax6	NP_038655.1	PAX	4..142	CDD:128645	92/137 (67%)
		Homeodomain	226..281	CDD:459649	10/91 (11%)