DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sv and Pax5

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_032808.1	Gene:	Pax5 / 18507	MGIID:	97489	Length:	391	Species:	Mus musculus

Alignment Length:	427	Identity:	177/427 - (41%)
Similarity:	207/427 - (48%)	Gaps:	139/427 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKA 239
            |||||||||||||||||||||||||||||||.||||||||||||||||||||||.|||||||.|.
Mouse    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKP 80

  Fly   240 GVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNKAAE 304
            |||||||||||||.||:.||.|||:||||||||||||||||.:|..|.||||||||||:|.|.
Mouse    81 GVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKV-- 143

  Fly   305 KAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNTNVSASASVHASIPT 369
                                                .|||           |....||.|:.:.|
Mouse   144 ------------------------------------QQPP-----------NQPVPASSHSIVST 161

  Fly   370 SGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNNNNNSSVNNNNNTES 434
            .....|. ||...:|.|:               |||:|||||          .:.|.:.|
Mouse   162 GSVTQVS-SVSTDSAGSS---------------YSISGILGI----------TSPSADTN----- 195

  Fly   435 SCKRKRIEAHDENHDTNIHS-DNDDGKRQRMSTYSGD----------------QLYTNIWSGKWC 482
              ||||.|...|:...|.|| ...|..|::|   .||                |.|::|::....
Mouse   196 --KRKRDEGIQESPVPNGHSLPGRDFLRKQM---RGDLFTQQQLEVLDRVFERQHYSDIFTTTEP 255

  Fly   483 IK----DDHKLLAEL--------GNLTASTGNCPATYYEASNGFSTTPISGSGATASGNDTSMLY 535
            ||    .::..:|.|        .|||:.|   ||....:..|..:.||      .:|.|
Mouse   256 IKPEQTTEYSAMASLAGGLDDMKANLTSPT---PADIGSSVPGPQSYPI------VTGRD----- 306

  Fly   536 DSITTISQTQSSIYTPAIGPSIGTGS-----LTPLVP 567
                 ::.|....|.|.:.|: |.||     ||.:||
Mouse   307 -----LASTTLPGYPPHVPPA-GQGSYSAPTLTGMVP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	109/123 (89%)
Pax5	NP_032808.1	PAX	16..140	CDD:128645	109/123 (89%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		53/55 (96%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		36/47 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		16/52 (31%)
		Pax2_C	285..389	CDD:289189	19/73 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2462
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3038
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43631
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5005
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.960