DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sv and Pax2

DIOPT Version :9

Sequence 1:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001355672.1	Gene:	Pax2 / 18504	MGIID:	97486	Length:	432	Species:	Mus musculus

Alignment Length:	477	Identity:	184/477 - (38%)
Similarity:	219/477 - (45%)	Gaps:	147/477 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 DSHSSQGSISG--DGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVS 225
            |.|......|.  .|||||||||||||||||||||||||||||||.|||||||||||||||||||
Mouse     2 DMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVS 66

  Fly   226 KILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPS 290
            |||.|||||||.|.|||||||||||||.|||.||.|||:||||||||||||||||.||..|.|||
Mouse    67 KILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPS 131

  Fly   291 VSSINRIVRNKAAEKAKHVHHHQQHHVSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSANSVNT 355
            |||||||:|.|                                    :.:|..||.:.:...|
Mouse   132 VSSINRIIRTK------------------------------------VQQPFHPTPDGAGTGV-- 158

  Fly   356 NVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGIQHGHHSHNN 420
                :|..|..:|::.:..|                 :|.:......|||||||||.
Mouse   159 ----TAPGHTIVPSTASPPV-----------------SSASNDPVGSYSINGILGIP-------- 194

  Fly   421 NNNSSVNNNNNTESSCKRKRIE-------AH--------------DENHDTNIHSDNDDG----- 459
                    .:|.|   ||||.|       ||              |.:..:..:.|:..|
Mouse   195 --------RSNGE---KRKREEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLR 248

  Fly   460 KRQRMSTYSGDQL-----------YTNIWSGKWCIKDDHKLLAELGN---LTASTGNCPATYYEA 510
            |..|..|::..||           |.:::.....||      :|.||   |.|.|....    |.
Mouse   249 KHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIK------SEQGNEYSLPALTPGLD----EV 303

  Fly   511 SNGFSTTPISGSGATASGNDTSMLYDSITTISQTQSSI--YTPAIGP----SIGTGSLTPLVPIS 569
            .:..|.:.....|:..||..|   |..:|....|.:::  |.|.:.|    |..|.:|..:||.|
Mouse   304 KSSLSASANPELGSNVSGTQT---YPVVTGRDMTSTTLPGYPPHVPPTGQGSYPTSTLAGMVPGS 365

  Fly   570 MHEMKLSANSIQEQTVPPFYTA 591
                :.|.|....    |.|||
Mouse   366 ----EFSGNPYSH----PQYTA 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sv	NP_524633.3	PAX	175..299	CDD:128645	111/123 (90%)
Pax2	NP_001355672.1	PAX	16..140	CDD:128645	111/123 (90%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		53/55 (96%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		38/47 (81%)
		homeodomain	255..>278	CDD:381795	4/22 (18%)
		Pax2_C	305..>390	CDD:372091	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2462
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3038
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43631
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970