DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and CLSTN3

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	XP_006719226.1	Gene:	CLSTN3 / 9746	HGNCID:	18371	Length:	968	Species:	Homo sapiens

Alignment Length:	1030	Identity:	290/1030 - (28%)
Similarity:	462/1030 - (44%)	Gaps:	233/1030 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEKSYHGLIRENETLVEIT-PLIKVNEE-------KICNFHILKKPYH--EIPFKIELVNNL--- 93
            :|..|.|::.||:..|.:. ||..::::       :||.|.:     |  .:||:..:::..
Human    41 IEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYAGEICGFRL-----HGSGVPFEAVILDKATGE 100

  Fly    94 GILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIE 151
            |:::|:..::||.:|.:.|.|.|..|...|       |:.|.||:.|.||||:||.|:|..|...
Human   101 GLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAA 165

  Fly   152 VDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSV 216
            |.||:||:.||||||.|.||:|.:..:|.||||..:.||.|||:|:|:|||.|.:.....:..:|
Human   166 VTEGKLYDRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTV 230

  Fly   217 VAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEED 280
            .||||..|.:| ...|.|:|:..|:..:.|..:||:|..|: .||.|||..||:.||     |..
Human   231 TAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGA-GSLALFPGIRLETCD-----EPL 289

  Fly   281 LRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLP---HGAEWTKELS--YDEGLEP 333
            ..|.::|.|:|.|::.|||||..:       |.:.....||||   ..|.||..||  |.:....
Human   290 WNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSL 354

  Fly   334 IFHFDGSTGVVVPA------------TVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSA 386
            |:.|:|:..|.||.            ::.||       |::....:|.......|..:|.|||:.
Human   355 IYWFNGTQAVQVPLGGPSGLGSGPQDSLSDH-------FTLSFWMKHGVTPNKGKKEEETIVCNT 412

  Fly   387 DDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKV 451
            ..::....|.:|.|..||:.||....     |....|.::.||:.:|||:|||||.||:|..: |
Human   413 VQNEDGFSHYSLTVHGCRIAFLYWPL-----LESARPVKFLWKLEQVCDDEWHHYALNLEFPT-V 471

  Fly   452 DLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLENRLK------------- 503
            .|:.||:.|:         |.:|.|..|........:|.||||:...:|:.|
Human   472 TLYTDGISFD---------PALIHDNGLIHPPRREPALMIGACWTEEKNKEKEKGDNSTDTTQGD 527

  Fly   504 -----HGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSD----NSQIKEN 559
                 |.|:|.::...|....:.:.|.|:|...|.|.|            .|.|    ...:|.:
Human   528 PLSIHHYFHGYLAGFSVRSGRLESREVIECLYACREGL------------DYRDFESLGKGMKVH 580

  Fly   560 IEMNEIYISAKNKHDIEQF---MRKVQYINTKQKPTVGRRNIEVLTTLNC-KNESSLRLPPIETY 620
            :..::..::.:. .|:|.|   ::.|.|:||.:..|.|.|.:.:.|.:.| ..||.:.:|.:|.|
Human   581 VNPSQSLLTLEG-DDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGY 644

  Fly   621 IMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIAISGTSN---KLVSYQEIKLGVHI---LEK 679
            ::|.:|.|                        |:|.:|||::   ..|.::... ||.:   |:.
Human   645 VVVLQPDA------------------------PQILLSGTAHFARPAVDFEGTN-GVPLFPDLQI 684

  Fly   680 TCIDSVSKN-NGKLEEK---------------NHIDSCSV-VVFPSLNPDHEDIKIDGDESLSSS 727
            ||  |:|.. ..|.:|.               :::|.|.: :|...|:|:.|.:.:|
Human   685 TC--SISHQVEAKKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLD-------- 739

  Fly   728 MDIKTNINKDGVEM---------IGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQY 783
               .|::.:.|:|:         .|.::|:.|..:||...|..:..|....|.|:|||::.:.:|
Human   740 ---TTSLQQRGLELTNTSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRLSCSEMNGRY 801

  Fly   784 KSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVY 848
            .|.|:.:.:.|||....:...::||.|             :...||.        :..|.|...:
Human   802 SSNEFIVEVNVLHSMNRVAHPSHVLSS-------------QQFLHRG--------HQPPPEMAGH 845

  Fly   849 SYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIARLKNNQKYIEHHQPC 913
            |.:          .||.:|.|..|     ..|||:|.|...||:..:.:.|:.:..:.:......
Human   846 SLA----------SSHRNSMIPSA-----ATLIIVVCVGFLVLMVVLGLVRIHSLHRRVSGAGGP 895

  Fly   914 PKISDD----GLIWDDSALTITINPM------QADVTSDASSESENSESEDEEVA 958
            |..|.|    .|.||||||||.:|||      |:.||.....:.|:.:|.|.|||
Human   896 PGASSDPKDPDLFWDDSALTIIVNPMESYQNRQSCVTGAVGGQQEDEDSSDSEVA 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	30/112 (27%)
		Cadherin_repeat	147..238	CDD:206637	42/91 (46%)
		LamG	<435..527	CDD:304605	30/109 (28%)
CLSTN3	XP_006719226.1	Cadherin_repeat	44..152	CDD:206637	30/112 (27%)
CLSTN3	XP_006719226.1	Cadherin_repeat	162..251	CDD:206637	41/88 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158967
Domainoid	1	1.000	260	1.000	Domainoid score	I1979
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1884
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm42291
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	O	PTHR14139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770