DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cals and clstn1

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	XP_005162326.1	Gene:	clstn1 / 777737	ZFINID:	ZDB-GENE-040426-1064	Length:	981	Species:	Danio rerio

Alignment Length:	1037	Identity:	316/1037 - (30%)
Similarity:	496/1037 - (47%)	Gaps:	194/1037 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEKSYHGLIRENETLVEI-TPLIKVN-----------------EEKICNFHILKKPYH--EIPFK 86
            :|.:|||::.||:..|.: .|||.::                 |.:||.|.|     |  .:||:
Zfish    35 IETTYHGIVTENDDKVLLDPPLIALDKDAPLRYAESFEVTFTKEGEICGFRI-----HGQNVPFE 94

  Fly    87 IELVNNL---GILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAP 141
            ..:::..   |:::|:..|:||.:|.:.|.|.|..|...|       |:.|.|||.|.|||||:|
Zfish    95 AVVLDKSTGEGVIRAKDKLDCELQKEHTFTIQAYDCGEGPDGGNMKKSHKATVHIQVNDVNEYSP 159

  Fly   142 TFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSH 206
            .|.|.||...|.||:.|:.|::|||.|.||:..|..:|.|||:..|.||:||.:|:|||||.|::
Zfish   160 VFKEKSYKATVIEGKKYDSIMKVEAVDADCSFQFSQICSYEIVTPDVPFTIDKDGNIKNTEKLNY 224

  Fly   207 KASHNHILSVVAYDCAM-KESAPIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDL 270
            .....:.|:|.||||.. :.|..::|.|.::..|:..:.|..:||:|..| |.||.|||:..|:.
Zfish   225 GKERMYKLTVTAYDCGKNRASEDVLVKINIKPTCKPSWQGFNKRIEYEPG-TGSLALFPSMHLET 288

  Fly   271 CDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLP---HGAEWTKEL 325
            |:     |....|.:||.|:|.||..|||||..:       |.:.....:|||   :.|.||..|
Zfish   289 CE-----EPITSIQASIMLETNHIGKGCDRDTYSEKSLHKLCGASSGTVELLPAPSNSANWTVGL 348

  Fly   326 SYDEG--LEPIFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADD 388
            ..|.|  .:.:|.|:|:..:.||..|:.  ....:||:|....||..    ....||.|:|::|.
Zfish   349 PTDNGHDSDQVFEFNGTQAIKVPEGVVS--TTLKEPFTISVWMRHGP----GGREKETILCNSDK 407

  Fly   389 HKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDL 453
            .:|||||.:|:|.||||:.|||:...|.:  .:.|||:.||:.:|||.||||||||:|..: |.|
Zfish   408 TEMNRHHYSLYVHNCRLVLLLRQEPTESE--SYKPAEFHWKLDQVCDKEWHHYVLNIEFPA-VTL 469

  Fly   454 FIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLEN-----------------R 501
            |:||..||..:        |.:|:|||.:. :.|.|.||||:|....                 |
Zfish   470 FVDGGTFEPFL--------VTEDYPLHTSK-IETQLTIGACWQDFSGHDNDTETLSEPLTGGSAR 525

  Fly   502 LKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIY 566
            :...|.|:::.:.:....:...:.|.|..||.|.|    .:|...|.:    |.:|.....|:..
Zfish   526 MTQFFRGNLAGLMIRSGKLENKKVIDCLYTCKEGL----DVQLPEEVA----SAVKVEFNPNQSS 582

  Fly   567 ISAKNKHDIEQF---MRKVQYINTKQKPTVGRRNIEVLTTLNCKNESS-LRLPPIETYIMVNEPI 627
            :|.:. .|||.|   |:.:.|:|::|.||.|.|::.|.||:.|.||.: :.:|..|.|:||.:|.
Zfish   583 LSLEG-DDIESFEKVMQHISYLNSRQFPTPGIRHLRVSTTVKCFNEETCISVPDSEGYVMVLQPE 646

  Fly   628 AP----LGIDIDVVSASLETSDLTPPSYSPKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKN 688
            .|    .||| .....:.|...:...:..|::.|..|..:.|   |::.......:...|...:.
Zfish   647 EPKISLSGID-HFARGAAEFESVEGVTLFPELRIVSTITREV---EVEAEAETEAEGEDDPTVQE 707

  Fly   689 NGKLEEKNH-IDSCSV-VVFPSLNPDHEDIKIDGDESLSSSMDI-KTNINKDGVEMIGKDTISNY 750
            ....||..| :|:|.| ||...||.|||.:::|..:....:::: .:|:   |:.:.|.:|::||
Zfish   708 TVVSEEIMHNLDTCEVTVVGEDLNGDHESLEVDLAQIQQRALEMSSSNV---GMVITGVNTMANY 769

  Fly   751 INVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTN--VLPSSLS 813
            ..||..:.|.|.......:|.|||.|::.:.:|.|.|:.:.:.|:|....:..:.|  |.|..:|
Zfish   770 EQVLHLIRYRNWHTEALFDRKFKLVCSELNGRYISNEFKVEVNVIHTANPMDHANNAMVQPQFIS 834

  Fly   814 KVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVT 878
            :|                         |.....:..::|::|        |..|.:..|.   ..
Zfish   835 QV-------------------------QHASVDLSGHNLVNT--------HQASVVPSAA---TI 863

  Fly   879 MLIILVSVFLAVLLCGVSIARLKNNQKYIEHHQPCPKISDDG----LIWDDSALTITINPMQA-- 937
            ::::.||..:.:::.||...|..        ||...:..::|    :.|||||||||:|||:.
Zfish   864 VIVVCVSFLVFMIILGVFRIRAA--------HQRTMRDQENGKENEMDWDDSALTITVNPMETYE 920

  Fly   938 -----------------------DVTSDASSESENSESEDEEVALKDGFTHINQLEWDNSNI 976
                                   |:||..|..||:...|.|:   :.|.:...|||||:|.:
Zfish   921 DQHSSEEEGDEEEEESEDGEEEDDITSAESDSSEDEAGEQED---QQGSSRQQQLEWDDSTL 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	36/122 (30%)
		Cadherin_repeat	147..238	CDD:206637	39/91 (43%)
		LamG	<435..527	CDD:304605	32/108 (30%)
clstn1	XP_005162326.1	Cadherin_repeat	38..156	CDD:206637	36/122 (30%)
clstn1	XP_005162326.1	Cadherin_repeat	165..255	CDD:206637	39/89 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594936
Domainoid	1	1.000	276	1.000	Domainoid score	I1705
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1844
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm24977
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	LDO	PTHR14139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3174
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800