DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and Clstn1

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	NP_075538.1	Gene:	Clstn1 / 65945	MGIID:	1929895	Length:	979	Species:	Mus musculus

Alignment Length:	1067	Identity:	317/1067 - (29%)
Similarity:	481/1067 - (45%)	Gaps:	259/1067 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEKSYHGLIRENETLVEI-TPLIKVN-----------------EEKICNFHILKKPYH--EIPFK 86
            ||.:|||::.||:..|.: .|||.::                 |.:||.|.|     |  .:||.
Mouse    38 LEPTYHGIVTENDNTVLLDPPLIALDKDSPLRFAESFEVTVTKEGEICGFKI-----HGQNVPFD 97

  Fly    87 IELVNNL---GILKARRTLNCENRKSYHFEICAIYC----DGT---PSNTANVHITVIDVNEYAP 141
            ..:|:..   ||::::..|:||.:|.|.|.|.|..|    |||   .|:.|.|||.|.|||||||
Mouse    98 AVVVDKSTGEGIIRSKEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAP 162

  Fly   142 TFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSH 206
            .|.|.||...|.||:.::.||||||.|.||:|.|..:|.||||..|.||::|.:|.|||||.|::
Mouse   163 VFKEKSYKAAVVEGKQHSSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNY 227

  Fly   207 KASHNHILSVVAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDL 270
            ...|.:.|:|.||||..|.:. .::|.|.|:..|...:.|...||:|..| |.:|.:||:..|:.
Mouse   228 GKEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPG-TGALAVFPSIHLET 291

  Fly   271 CDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLPHGA---EWTKEL 325
            ||     |....:.:::.|:|.||..|||||..:       |.:.....:|||..:   .||..|
Mouse   292 CD-----EPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGL 351

  Fly   326 SYDEG--LEPIFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADD 388
            ..|.|  .:.:|.|:|:..|.:|..|:. .| ..:||:|....||..    ....||.|:||:|.
Mouse   352 PTDNGHDSDQVFEFNGTQAVRIPDGVVT-LD-PKEPFTISVWMRHGP----FGRKKETILCSSDK 410

  Fly   389 HKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDL 453
            ..|||||.:|:|..|||:||||::.:|.  ..:.|||:.||:.:|||.:|||:|||||..| |.|
Mouse   411 TDMNRHHYSLYVHGCRLVFLLRQDPSEE--KKYRPAEFHWKLNQVCDEDWHHFVLNVEVPS-VTL 472

  Fly   454 FIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLEN------------------ 500
            ::||:        .|....|.:|:|||... :.|.|.:|||:|....
Mouse   473 YVDGI--------PHEPFSVTEDYPLHPTK-IETQLVVGACWQEYSGVESGNETEPATMASAGGD 528

  Fly   501 -RLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNE 564
             .:...|.|:::.:.|....:...:.|.|..||.|.|....|..:|.      ..||:.:.....
Mouse   529 LHMTQFFRGNLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDANR------GVQIQASSSQAV 587

  Fly   565 IYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCKNESS-LRLPPIETYIMVNEPIA 628
            :.:...|..::::.|:.:.|:|::|.||.|.|.:::.:|:.|.||:: :.:||:|.|:||.:|
Mouse   588 LTLEGDNVGELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQP-- 650

  Fly   629 PLGIDIDVVSASLETSDLTPPSYSPKIAISGTSN--KLVSYQEIKLGVHIL-EKTCIDSVSKN-- 688
                                  ..|||::||..:  :..|..|...|:.:. |...|.::::.
Mouse   651 ----------------------EEPKISLSGVHHFARAASEFESAEGISLFPELRIISTITREVE 693

  Fly   689 ---NGK----------LEEKNH-IDSCSVVV-FPSLNPDHEDIKID-------GDESLSSSMDIK 731
               :|.          .||..| :|:|.|.| ...||.:.|.:::|       |.|:..|.:
Mouse   694 PEADGSEDPTVQESLVSEEIVHDLDTCEVTVEGDELNAEQESLEVDVTRLQQKGIEASHSDL--- 755

  Fly   732 TNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLH 796
                  ||...|.:|:::|..||..|.|.|......|:|.|||.|::.:.:|.|.|:.:.:.|:|
Mouse   756 ------GVVFTGVETMASYEEVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIH 814

  Fly   797 PKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEP 861
                                    |.|                  |.|         |.|::...
Mouse   815 ------------------------TAN------------------PVE---------HANHMAAQ 828

  Fly   862 KSHIH----SFI----HKAEGSH---------VTMLIILVSVFLAVLLCGVSIARLKNNQKYIEH 909
            ...:|    ||:    |.....|         ..::::.||..:.:::.||...|..
Mouse   829 PQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAA-------- 885

  Fly   910 HQPCPKISDDG----LIWDDSALTITINPMQADVTSDASSESENSE------------------- 951
            ||...:..|.|    :.|||||||||:|||:......:|.|.|..|
Mouse   886 HQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEEDITSAES 950

  Fly   952 --SEDEEVALKDGFTHINQLEWDNSNI 976
              ||:||....||.....|||||:|.:
Mouse   951 ESSEEEEGGPGDGQNATRQLEWDDSTL 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	40/122 (33%)
		Cadherin_repeat	147..238	CDD:206637	43/91 (47%)
		LamG	<435..527	CDD:304605	29/110 (26%)
Clstn1	NP_075538.1	Cadherin_repeat	41..159	CDD:206637	40/122 (33%)
		Cadherin_repeat	168..258	CDD:206637	42/89 (47%)
		LamG	365..>478	CDD:304605	53/129 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..979		17/63 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849345
Domainoid	1	1.000	252	1.000	Domainoid score	I2077
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1926
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48981
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm44343
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	LDO	PTHR14139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3174
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790