DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and Clstn2

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	XP_036011063.1	Gene:	Clstn2 / 64085	MGIID:	1929897	Length:	1006	Species:	Mus musculus

Alignment Length:	1005	Identity:	299/1005 - (29%)
Similarity:	480/1005 - (47%)	Gaps:	206/1005 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEKSYHGLIRE-NETLVEITPLIKVNEE-------KICNFHILKKPYH--EIPFKIELVNNL--- 93
            :|.||||:|.| |:|::...||:.::::       :||.|.|     |  |:||:..::|..
Mouse    86 IETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKI-----HGQELPFEAVVLNKTSGE 145

  Fly    94 GILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIE 151
            |.|:|:..::||.:|.|.|.|.|..|...|       |:.|.|||.|.||||:||||.||:|...
Mouse   146 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAI 210

  Fly   152 VDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSV 216
            |.||::|:.||:|||.|:||:|.:..:|.|||:..|.||:||..|:|:|||.||:...|.:.:.|
Mouse   211 VTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILV 275

  Fly   217 VAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEED 280
            .||||..|.:| ..:|.:.|:.||:..:....:||:|..|| .|:.|||:..|:.||.:..:
Mouse   276 TAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGS-GSMPLFPSIHLETCDGAVSS--- 336

  Fly   281 LRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLPH---GAEWTKELSYDEGLEPIF 335
              :..:..|:|.:|..||||:..:       |.:...:.||||.   ...||..|..|.. |.||
Mouse   337 --LQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSS-EMIF 398

  Fly   336 HFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFV 400
            .|||..|..:|..::.. :.:.| |:|....:|.....:... ||.|:|::|..:|||||.||:|
Mouse   399 KFDGRQGAKIPDGIVPK-NLTDQ-FTITMWMKHGPSPGVRAE-KETILCNSDKTEMNRHHYALYV 460

  Fly   401 RNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIE 465
            .||||:|||||:|::.|  .|.|||:.||:.::||.|||:||:||| ...|.|::||..:|..:
Mouse   461 HNCRLVFLLRKDFDQAD--TFRPAEFHWKLDQICDKEWHYYVINVE-FPVVTLYMDGATYEPYL- 521

  Fly   466 NRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLE---NRLKHGFNGDISEVKVSLNSVLTAEDIK 527
                   |.:|||:|.:| :...|.:|||:|..|   .|....|:|.::.:.:....:.:.:.|.
Mouse   522 -------VTNDWPIHPSH-IAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVIS 578

  Fly   528 CGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPT 592
            |...|.|      .|..|:.:|.....:...|...:.:.:...:..:|.:.::||.|||::|.||
Mouse   579 CLQACKE------GLDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPT 637

  Fly   593 VGRRNIEVLTTLNCKNES-SLRLPPIETYIMVNEPIAP------------------------LGI 632
            .|.|.:.:.:.:.|..|. .:.:|.::.||||.:.|.|                        |..
Mouse   638 AGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFP 702

  Fly   633 DIDVVSASLET---SDLTPPSYSPKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKNNGKLEE 694
            ||.:||...:|   .|:.....:||.|:                                  |||
Mouse   703 DIKIVSTFAKTEASGDMRATGTAPKSAV----------------------------------LEE 733

  Fly   695 KNH-IDSCSVVVF-PSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSL 757
            ..| :|.|.::|. ..|:|..|.::::..|.....:| .|| :..|..:.|..:::.|..||..|
Mouse   734 MLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLD-ATN-STAGYSIYGVGSMNRYEQVLHHL 796

  Fly   758 VYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKS-TN---VLPSSLSKVNFI 818
            .|.|..|.....|.|::.|::.:.:|.|.|:.|.::|||..:...|. .|   |.|..|..|
Mouse   797 RYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVRVSDKEHVNHLIVQPPFLQSV--- 858

  Fly   819 GNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIIL 883
                                ::..|.|.:...|::.:                     :..::|:
Mouse   859 --------------------HHPETRSSIQRSSVVPS---------------------IATVVII 882

  Fly   884 VSVFLAVLLCGVSIARLK-NNQKYIEHHQPCPKISDDGLIWDDSALTITINPMQ----------- 936
            :||.:.|.:..:.:.|:: .:|.:|:..:...:...|   |||||||||:|||:
Mouse   883 ISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKEAEMD---WDDSALTITVNPMEKHEGPGNGEDE 944

  Fly   937 ----------ADVTSDASSESENSESEDEE 956
                      .:.:|.:||.|::||.|:||
Mouse   945 TTEVEEEEEAEEGSSSSSSGSDDSEEEEEE 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	39/112 (35%)
		Cadherin_repeat	147..238	CDD:206637	40/91 (44%)
		LamG	<435..527	CDD:304605	29/94 (31%)
Clstn2	XP_036011063.1	Cadherin_repeat	89..197	CDD:206637	39/112 (35%)
Clstn2	XP_036011063.1	Cadherin_repeat	207..298	CDD:206637	40/90 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849346
Domainoid	1	1.000	252	1.000	Domainoid score	I2077
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49698
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1926
Isobase	1	0.950	-	0	Normalized mean entropy	S5789
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm44343
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	O	PTHR14139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3174
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750