Protein Alignment Cals and CLSTN2

DIOPT Version :10

• Sequence 1: NP_001259086.1
• Gene: Cals / 43824
• FlyBaseID: FBgn0039928
• Length: 979
• Species: Drosophila melanogaster
• Sequence 2: NP_071414.2
• Gene: CLSTN2 / 64084
• HGNCID: 17448
• Length: 955
• Species: Homo sapiens
• Alignment Length: 1013
• Identity: 311/1013 - (30%)
• Similarity: 499/1013 - (49%)
• Gaps: 181/1013 - (17%)

  Fly    42 LEKSYHGLIRE-NETLVEITPLIKVNEE-------KICNFHILKKPYH--EIPFKIELVNNL--- 93
            :|.||||:|.| |:|::...||:.::::       :||.|.|     |  |:||:..::|..
Human    44 IETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKI-----HGQELPFEAVVLNKTSGE 103

  Fly    94 GILKARRTLNCENRKSYHFEICAIYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIE 151
            |.|:|:..::||.:|.|.|.|.|..|...|       |:.|.|||.|.||||:||||.||:|...
Human   104 GRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAV 168

  Fly   152 VDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSV 216
            |.||::|:.||:|||.|:||:|.:..:|.|||:..|.||:||..|:|:|||.||:...|.:.:.|
Human   169 VTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILV 233

  Fly   217 VAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEED 280
            .||||..|.:| ..:|.:.|:.||:..:....:||:|..|| .|:.|||:..|:.||.:..:
Human   234 TAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGS-GSMPLFPSIHLETCDGAVSS--- 294

  Fly   281 LRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLPH---GAEWTKELSYDEGLEPIF 335
            |:|.:.  |:|.:|..||||:..:       |.:...:.||||.   ...||..|..|.. |.||
Human   295 LQIVTE--LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSS-EMIF 356

  Fly   336 HFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFV 400
            .|||..|..||..::.. :.:.| |:|....:|.....:... ||.|:|::|..:|||||.||:|
Human   357 KFDGRQGAKVPDGIVPK-NLTDQ-FTITMWMKHGPSPGVRAE-KETILCNSDKTEMNRHHYALYV 418

  Fly   401 RNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIE 465
            .||||:|||||:|::.|  .|.|||:.||:.::||.|||:||:||| ...|.|::||..:|..:
Human   419 HNCRLVFLLRKDFDQAD--TFRPAEFHWKLDQICDKEWHYYVINVE-FPVVTLYMDGATYEPYL- 479

  Fly   466 NRHSNPEVIDDWPLHAAHGVNTSLAIGACYQSLE---NRLKHGFNGDISEVKVSLNSVLTAEDIK 527
                   |.:|||:|.:| :...|.:|||:|..|   .:....|:|.::.:.:....:.:.:.|.
Human   480 -------VTNDWPIHPSH-IAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVIS 536

  Fly   528 CGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPT 592
            |...|.|      .|..|:.:|.....:...|...:.:.:...:..:|.:.::||.|||::|.||
Human   537 CLQACKE------GLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPT 595

  Fly   593 VGRRNIEVLTTLNCKNES-SLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIA 656
            .|.|.::|.:.:.|..|. .:.:|.::.|:||.:.|                        .|:|.
Human   596 AGVRRLKVSSKVQCFGEDVCISIPEVDAYVMVLQAI------------------------EPRIT 636

  Fly   657 ISGT------------SNKLVSYQEIKLGVHILEKT----CIDSVSKNNGKLEEKNH-IDSCSVV 704
            :.||            :..:..:.:||: |....||    .:.:....:..|||..| :|.|.::
Human   637 LRGTDHFWRPAAQFESARGVTLFPDIKI-VSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDIL 700

  Fly   705 VF-PSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYL 768
            |. ..|:|..|.::::..|.....:| .|| :..|..:.|..::|.|..||..:.|.|.:||...
Human   701 VIGGDLDPRQECLELNHSELHQRHLD-ATN-STAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLE 763

  Fly   769 NRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGS 833
            .|.|::.|::.:.:|.|.|:.|.:::||..|.                    :|.|   |.|...
Human   764 ARRFRIKCSELNGRYTSNEFNLEVSILHEDQV--------------------SDKE---HVNHLI 805

  Fly   834 VNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLAVLLCGVSIA 898
            |      ||.          ...:|..|:|. .|..|.:....:..::|::||.:.|.:..:.:.
Human   806 V------QPP----------FLQSVHHPESR-SSIQHSSVVPSIATVVIIISVCMLVFVVAMGVY 853

  Fly   899 RLK-NNQKYIEHHQPCPKISDDGLIWDDSALTITINPM-------------------QADVTSDA 943
            |:: .:|.:|:..:...:...|   |||||||||:|||                   :|:....:
Human   854 RVRIAHQHFIQETEAAKESEMD---WDDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEEMSS 915

  Fly   944 SSESENSESEDEEVALKDGFTHIN-----QLEWDNSNI 976
            ||.|::||.|:||..:..|....|     |||||:|.:
Human   916 SSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTL 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	39/112 (35%)
		CA_like	148..235	CDD:481204	39/87 (45%)
		Laminin_G_3	<435..527	CDD:463865	28/94 (30%)
		CLSTN_C	573..936	CDD:466150	94/401 (23%)
CLSTN2	NP_071414.2	Cadherin_repeat	47..155	CDD:206637	39/112 (35%)
		Cadherin_repeat	165..256	CDD:206637	40/90 (44%)
		CLSTN_C	546..892	CDD:466150	97/415 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	887..955		19/67 (28%)