DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and Clstn3

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	NP_705728.1	Gene:	Clstn3 / 232370	MGIID:	2178323	Length:	956	Species:	Mus musculus

Alignment Length:	1056	Identity:	297/1056 - (28%)
Similarity:	473/1056 - (44%)	Gaps:	227/1056 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVLICFELLFAG-VETSSENDDEYLTQKEIILEKSYHGLIRENETLVEIT-PLIKVNEE------ 68
            :.|:...||.|. ::.||.|.   ..:.:..:|..|.|::.||:..|.:. ||..::::
Mouse     1 MTLLLVSLLLASLLQISSGNK---ANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYA 62

  Fly    69 -KICNFHILKKPYH--EIPFKIELVNNL---GILKARRTLNCENRKSYHFEICAIYC----DGT- 122
             :||.|.:     |  .:||:..:::..   |:::|:..::||.:|.:.|.|.|..|    |||
Mouse    63 GEICGFRL-----HGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDGTN 122

  Fly   123 --PSNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILN 185
              .|:.|.||:.|.||||:||.|:|..|...|.||:||:.||||||.|.||:|.:..:|.||||.
Mouse   123 TKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILT 187

  Fly   186 NDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMKESA-PIMVSIKVRRVCETKFVGMPER 249
            .:.||.|||:|:|:|||.|.:.....:..:|.||||..|.:| ...|.|:|:..|:..:.|..:|
Mouse   188 PNTPFLIDNDGNIENTEKLQYSGEKLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKR 252

  Fly   250 IDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTS 307
            |:|..|: .||.|||..||:.||     |....|.::|.|:|.|::.|||||..:       |.:
Mouse   253 IEYAPGA-GSLALFPGIRLETCD-----EPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGA 311

  Fly   308 GQKVKDLLP---HGAEWTKELS--YDEGLEPIFHFDGSTGVVVP-----ATVIDHYDFSSQPFSI 362
            .....||||   ..|.||..||  |.:....|:.|:|:..|.||     .......|..|..|::
Mouse   312 ATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGFSDHFTL 376

  Fly   363 LTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWR 427
            ....:|:......|..:|.|||:...::....|.:|.|..||:.||....     |....|.::.
Mouse   377 SFWMKHSVTPSKGKKEEETIVCNTVQNEDGYSHYSLTVHGCRIAFLYWPL-----LESARPVKFL 436

  Fly   428 WKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIG 492
            ||:.:|||:|||||.||:|..: |.|:.||:.|:         |.:|.|..|........:|.||
Mouse   437 WKLEQVCDDEWHHYALNLEFPT-VTLYTDGISFD---------PALIHDNGLIHPPRREPALMIG 491

  Fly   493 ACYQSLENRLK------------------HGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAP 539
            ||:...:|:.|                  |.|:|.::...|....:.:.|.|:|...|.|.|
Mouse   492 ACWTEEKNKEKKGGENSTDTASGDPLLIHHYFHGYLAGFSVRSGRLESREVIECLYACREGL--- 553

  Fly   540 KPLQSNNEKSYSD----NSQIKENIEMNEIYISAKNKHDIEQF---MRKVQYINTKQKPTVGRRN 597
                     .|.|    ...:|.::..::..::.:. .|:|.|   ::.|.|:||.:..|.|.|.
Mouse   554 ---------DYRDFESLGKGMKVHVNPSQSLLTLEG-DDVETFNHALQHVAYMNTLRFATPGVRP 608

  Fly   598 IEVLTTLNC-KNESSLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSPKIAISGTS 661
            :.:.|.:.| ..||.:.:|.:|.|::|.:|.|                        |:|.:|||:
Mouse   609 LRLTTAVKCFSEESCVSIPEVEGYVVVLQPDA------------------------PQILLSGTA 649

  Fly   662 N---KLVSYQEIKLGVHI---LEKTCIDSVSKN-NGKLEEK---------------NHIDSCSV- 703
            :   ..|.::..: ||.:   |:.||  |:|.. ..|.:|.               :::|.|.:
Mouse   650 HFARPAVDFEGPE-GVPLFPDLQITC--SISHQVEAKADESWQGTVTDTRMSDEIVHNLDGCEIS 711

  Fly   704 VVFPSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEM---------IGKDTISNYINVLRSLVY 759
            :|...|:|:.|.:.:|           ..::.:.|:|:         .|.:||:.|..:||...|
Mouse   712 LVGDDLDPERESLLLD-----------MASLQQRGLELTNTSAYLTIAGVETITVYEEILRQARY 765

  Fly   760 SNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNE 824
            ..:..|....|.|:|||::.:.:|.|.|:.:.:.|||....:...::||.|             :
Mouse   766 QLRHGAALYARKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSS-------------Q 817

  Fly   825 TSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLIILVSVFLA 889
            ...||.        :..|.|...:|.:          .||.:|.:..|     ..|||:|.|...
Mouse   818 QFLHRG--------HQPPPEMAGHSLA----------SSHRNSMVPSA-----ATLIIVVCVGFL 859

  Fly   890 VLLCGVSIARLKNNQKYI------EHHQPCPKISDDGLIWDDSALTITINPM------QADVTSD 942
            ||:..:.:.|:.:..:.:      ......||  |..|.||||||||.:|||      |..|...
Mouse   860 VLMVILGLVRIHSLHRRVSGTGGPSGASTDPK--DPDLFWDDSALTIIVNPMESYQNQQTCVAGV 922

  Fly   943 ASSESENSESEDEEVA 958
            |..:.|..:|.|.|.|
Mouse   923 AGGQQEEEDSSDSEAA 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	32/112 (29%)
		Cadherin_repeat	147..238	CDD:206637	42/91 (46%)
		LamG	<435..527	CDD:304605	30/109 (28%)
Clstn3	NP_705728.1	Cadherin_repeat	32..140	CDD:206637	32/112 (29%)
		Cadherin_repeat	150..239	CDD:206637	41/88 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..956		8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849347
Domainoid	1	1.000	252	1.000	Domainoid score	I2077
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1926
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm44343
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	O	PTHR14139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770