Protein Alignment Cals and CLSTN1

DIOPT Version :10

• Sequence 1: NP_001259086.1
• Gene: Cals / 43824
• FlyBaseID: FBgn0039928
• Length: 979
• Species: Drosophila melanogaster
• Sequence 2: NP_001009566.1
• Gene: CLSTN1 / 22883
• HGNCID: 17447
• Length: 981
• Species: Homo sapiens
• Alignment Length: 1072
• Identity: 317/1072 - (29%)
• Similarity: 482/1072 - (44%)
• Gaps: 267/1072 - (24%)

  Fly    42 LEKSYHGLIRENETLVEI-TPLIKVN-----------------EEKICNFHILKKPYH--EIPFK 86
            ||.:|||::.||:..|.: .|||.::                 |.:||.|.|     |  .:||.
Human    38 LEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKI-----HGQNVPFD 97

  Fly    87 IELVNNL---GILKARRTLNCENRKSYHFEICAIYC----DGT---PSNTANVHITVIDVNEYAP 141
            ..:|:..   |:::::..|:||.:|.|.|.|.|..|    |||   .|:.|.|||.|.|||||||
Human    98 AVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAP 162

  Fly   142 TFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILNNDEPFSIDNEGSIKNTEPLSH 206
            .|.|.||...|.||:.|:.||||||.|.||:|.|..:|.|||:..|.||::|.:|.|||||.|::
Human   163 VFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNY 227

  Fly   207 KASHNHILSVVAYDCAMKESA-PIMVSIKVRRVCETKFVGMPERIDYTSGSTESLQLFPNARLDL 270
            ...|.:.|:|.||||..|.:. .::|.|.::..|...:.|...||:|..| |.:|.:|||..|:.
Human   228 GKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPG-TGALAVFPNIHLET 291

  Fly   271 CDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTSGQKVKDLLPH---GAEWTKEL 325
            ||     |....:.:::.|:|.||..|||||..:       |.:.....:|||.   ...||..|
Human   292 CD-----EPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGL 351

  Fly   326 SYDEG--LEPIFHFDGSTGVVVPATVIDHYDFSSQPFSILTLFRHNSQVEINKHVKEHIVCSADD 388
            ..|.|  .:.:|.|:|:..|.:|..|:.  ....:||:|....||..    ....||.|:||:|.
Human   352 PTDNGHDSDQVFEFNGTQAVRIPDGVVS--VSPKEPFTISVWMRHGP----FGRKKETILCSSDK 410

  Fly   389 HKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDL 453
            ..|||||.:|:|..||||||.|::.:|.  ..:.|||:.||:.:|||.||||||||||..| |.|
Human   411 TDMNRHHYSLYVHGCRLIFLFRQDPSEE--KKYRPAEFHWKLNQVCDEEWHHYVLNVEFPS-VTL 472

  Fly   454 FIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTSLAIGACYQ---SLEN--------------- 500
            ::||        ..|....|.:|:|||.:. :.|.|.:|||:|   .:||
Human   473 YVDG--------TSHEPFSVTEDYPLHPSK-IETQLVVGACWQEFSGVENDNETEPVTVASAGGD 528

  Fly   501 -RLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSYSDNSQIKENIEMNE 564
             .:...|.|:::.:.:....:...:.|.|..||.|.|    .||...:.  ....||:.:.....
Human   529 LHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGL----DLQVLEDS--GRGVQIQAHPSQLV 587

  Fly   565 IYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCKNESS-LRLPPIETYIMVNEPIA 628
            :.:..::..::::.|:.:.|:|::|.||.|.|.:::.:|:.|.||:: :.:||::.|:||.:|
Human   588 LTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQP-- 650

  Fly   629 PLGIDIDVVSASLETSDLTPPSYSPKIAISGTSN--KLVSYQEIKLGVHILEKTCI--------- 682
                                  ..|||::||..:  :..|..|...||.:..:..|
Human   651 ----------------------EEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVE 693

  Fly   683 -------DSVSKNNGKLEEKNH-IDSCSVVV-FPSLNPDHEDIKID-------GDESLSSSMDIK 731
                   |...:.:...||..| :|:|.|.| ...||.:.|.:::|       |.|..||.:
Human   694 PEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSEL--- 755

  Fly   732 TNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLH 796
                  |:...|.||:::|..||..|.|.|......|:|.|||.|::.:.:|.|.|:.:.:.|:|
Human   756 ------GMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIH 814

  Fly   797 PKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEP 861
                                    |.|                  |.|         |.|::...
Human   815 ------------------------TAN------------------PME---------HANHMAAQ 828

  Fly   862 KSHIH----SFI----HKAEGSH---------VTMLIILVSVFLAVLLCGVSIARLKNNQKYIEH 909
            ...:|    ||:    |.....|         ..::::.||..:.:::.||...|..
Human   829 PQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAA-------- 885

  Fly   910 HQPCPKISDDG----LIWDDSALTITINPMQA--------------------------DVTSDAS 944
            |:...:..|.|    :.|||||||||:|||:.                          |:|   |
Human   886 HRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDIT---S 947

  Fly   945 SESENSESEDEEVALKDGFTHINQLEWDNSNI 976
            :|||:||.|:.|.......|...|||||:|.:
Human   948 AESESSEEEEGEQGDPQNATRQQQLEWDDSTL 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	39/122 (32%)
		CA_like	148..235	CDD:481204	41/87 (47%)
		Laminin_G_3	<435..527	CDD:463865	32/110 (29%)
		CLSTN_C	573..936	CDD:466150	95/411 (23%)
CLSTN1	NP_001009566.1	Cadherin_repeat	41..159	CDD:206637	39/122 (32%)
		Cadherin_repeat	168..258	CDD:206637	42/89 (47%)
		Laminin_G_3	365..>477	CDD:463865	54/128 (42%)
		CLSTN_C	566..919	CDD:466150	100/446 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	915..981		18/68 (26%)