DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and Clstn2

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	NP_599204.1	Gene:	Clstn2 / 171394	RGDID:	621151	Length:	965	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	311/1053 - (29%)
Similarity:	486/1053 - (46%)	Gaps:	233/1053 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CIVLICFELLFAGVETSSENDDEYLTQKEIIL-----------EKSYHGLIRENETLVEITPLIK 64
            |:|.:   ||..||.:...:.|...:::..:|           |.||||:|.||...|.:.|.|.
  Rat     7 CLVPL---LLALGVGSGGGSGDGGDSRRRRLLAAKVNKHKPWIETSYHGVITENNDTVILDPTIV 68

  Fly    65 VNEE--------KICNFHILKKPYH--EIPFKIELVNNL---GILKARRTLNCENRKSYHFEICA 116
            ..::        :||.|.|     |  |:||:..::|..   |.|:|:..::||.:|.|.|.|.|
  Rat    69 ALDKDAPVPFAGEICAFKI-----HGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQA 128

  Fly   117 IYCDGTP-------SNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPL 174
            ..|...|       |:.|.|||.|.||||:||||.||:|...|.||::|:.||:|||.|:||:|.
  Rat   129 YDCGAGPQEAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQ 193

  Fly   175 FGDVCKYEILNNDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMKESA-PIMVSIKVRRV 238
            :..:|.|||:..|.||:||..|:|:|||.||:.....:.:.|.||||..|.:| ..:|.:.|:.|
  Rat   194 YSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQRQYEILVTAYDCGQKPAAQDTLVQVDVKPV 258

  Fly   239 CETKFVGMPERIDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDIS 303
            |:..:....:||:|..|| .|:.|||...|:.||.:..:     :..:..|:|.:|..||||:..
  Rat   259 CKPGWQDWTKRIEYQPGS-GSMPLFPGIHLETCDGAVSS-----LQVTAELQTNYIGKGCDRETY 317

  Fly   304 N-------CTSGQKVKDLLPH---GAEWTKELSYDEGLEPIFHFDGSTGVVVPATVIDHYDFSSQ 358
            :       |.:...:.||||.   ...||..|..|.. |.||.|||..|..:|..::.. :.:.|
  Rat   318 SEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSS-EMIFKFDGRQGAKIPDGIVPK-NLTDQ 380

  Fly   359 PFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNIFSP 423
             |:|....:|.....:... ||.|:|::|..:|||||.||:|.||||:|||||:|::.|  .|.|
  Rat   381 -FTITMWMKHGPSPGVRAE-KETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQAD--TFRP 441

  Fly   424 AEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGVNTS 488
            ||:.||:.::||.|||:||:||| ...|.|::||..:|..:        |.:|||:|.:| :...
  Rat   442 AEFHWKLDQICDKEWHYYVINVE-FPVVTLYMDGATYEPYL--------VTNDWPIHPSH-IAMQ 496

  Fly   489 LAIGACYQSLE---NRLKHGFNGDISEVKVSLNSVLTAEDIKCGTTCAEHLLAPKPLQSNNEKSY 550
            |.:|||:|..|   .|....|:|.::.:.:....:.:.:.|.|...|.|      .|..|:.:|.
  Rat   497 LTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKE------GLDINSLESL 555

  Fly   551 SDNSQIKENIEMNEIYISAKNKHDIEQFMRKVQYINTKQKPTVGRRNIEVLTTLNCKNES-SLRL 614
            ....:...|...:.:.:...:..:|.|.::||.|||::|.||.|.|.:.:.:.:.|..|. .:.:
  Rat   556 GRGIKYHFNPSQSILVMEGDDIGNINQALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISI 620

  Fly   615 PPIETYIMVNEPIAP------------------------LGIDIDVVSASLET---SDLTPPSYS 652
            |.::.||||.:.|.|                        |..||.::|...:|   .||.....:
  Rat   621 PDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIISTFAKTEASGDLRATGTA 685

  Fly   653 PKIAISGTSNKLVSYQEIKLGVHILEKTCIDSVSKNNGKLEEKNH-IDSCSVVVF-PSLNPDHED 715
            ||.|:                                  |||..| :|.|.::|. ..|:|..|.
  Rat   686 PKSAV----------------------------------LEEMLHNLDFCDILVLGGDLDPRQEC 716

  Fly   716 IKIDGDESLSSSMDIKTNINKDGVEMIGKDTISNYINVLRSLVYSNKKPAYYLNRVFKLSCAQQS 780
            ::::..|.....:| .|| :..|..:.|..::|.|..||..|.|.|..|.....|.|::.|::.:
  Rat   717 LELNHSELHQRHLD-ATN-STAGYSIYGVGSMSRYEQVLHHLRYRNWHPTSLETRRFQIKCSELN 779

  Fly   781 SQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVNFIGNTDNETSFHRNSGSVNGNDNNQPTES 845
            .:|.|.|:.|.::|||..:.                    :|.|
  Rat   780 GRYTSNEFNLEVSVLHEVRV--------------------SDTE--------------------- 803

  Fly   846 KVYSYSLLHTNN--VQEPKSHIHSFIHKAEGS---------HVTMLIILVSVFLAVLLCGVSIAR 899
                    |.|:  ||.|  .:.|..|....|         .:..::|::||.:.|.:..:.:.|
  Rat   804 --------HVNHLIVQPP--FLQSVYHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGVYR 858

  Fly   900 LK-NNQKYIEHHQPCPKISDDGLIWDDSALTITINPMQ--------ADVT------------SDA 943
            :: .:|.:|:..:...:...|   |||||||||:|||:        .|.|            |.:
  Rat   859 VRIAHQHFIQETEAAKEAEMD---WDDSALTITVNPMEKHEGPGHGEDETEGEEEEEAEEGMSSS 920

  Fly   944 SSESENSESEDEE 956
            ||.|::||.|:||
  Rat   921 SSGSDDSEEEEEE 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	39/112 (35%)
		Cadherin_repeat	147..238	CDD:206637	39/91 (43%)
		LamG	<435..527	CDD:304605	29/94 (31%)
Clstn2	NP_599204.1	Cadherin_repeat	49..157	CDD:206637	39/112 (35%)
		Cadherin_repeat	167..258	CDD:206637	39/90 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..965		13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352963
Domainoid	1	1.000	250	1.000	Domainoid score	I2041
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49698
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1784
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm46441
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	O	PTHR14139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910