DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cals and Clstn3

DIOPT Version :9

Sequence 1:	NP_001259086.1	Gene:	Cals / 43824	FlyBaseID:	FBgn0039928	Length:	979	Species:	Drosophila melanogaster
Sequence 2:	NP_599203.1	Gene:	Clstn3 / 171393	RGDID:	621153	Length:	957	Species:	Rattus norvegicus

Alignment Length:	1064	Identity:	296/1064 - (27%)
Similarity:	472/1064 - (44%)	Gaps:	242/1064 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVLICFELLFAG-VETSSENDDEYLTQKEIILEKSYHGLIRENETLVEIT-PLIKVNEE------ 68
            :.|:...||.|. ::.||.|.   ..:.:..:|..|.|::.||:..|.:. ||..::::
  Rat     1 MTLLLVSLLLASLLQISSGNK---ANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYA 62

  Fly    69 -KICNFHILKKPYH--EIPFKIELVNNL---GILKARRTLNCENRKSYHFEICAIYC----DGT- 122
             :||.|.:     |  .:|||..:::..   |:::|:..::||.:|.:.|...|..|    ||.
  Rat    63 GEICGFRL-----HGSGVPFKAVILDKATGEGLIRAKEPVDCEAQKEHTFTTQAYDCVDGPDGAN 122

  Fly   123 --PSNTANVHITVIDVNEYAPTFLEPSYVIEVDEGRLYNEILRVEASDKDCTPLFGDVCKYEILN 185
              .|:.|.||:.|.||||:||.|:|..|...|.||:||:.||||||.|.||:|.:..:|.||||.
  Rat   123 TKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQICYYEILT 187

  Fly   186 NDEPFSIDNEGSIKNTEPLSHKASHNHILSVVAYDCAMKESA-PIMVSIKVRRVCETKFVGMPER 249
            .:.||.|||:|:|:|||.|.:.....:..:|.||||..|.:| ...|.|:|:..|:..:.|..:|
  Rat   188 PNTPFLIDNDGNIENTEKLQYSGEKLYKFTVTAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKR 252

  Fly   250 IDYTSGSTESLQLFPNARLDLCDISCKNEEDLRIHSSIALKTKHISFGCDRDISN-------CTS 307
            |:|..|: .||.|||..||:.||     |....|.::|.|:|.|::.|||||..:       |.:
  Rat   253 IEYAPGA-GSLALFPGIRLETCD-----EPLWNIQATIELQTSHVAKGCDRDNYSERALRKLCGA 311

  Fly   308 GQKVKDLLP---HGAEWTKELS--YDEGLEPIFHFDGSTGVVVPA------------TVIDHYDF 355
            .....||||   ..|.||..||  |.:....|:.|:|:..|.||.            .:.||
  Rat   312 ATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGLSDH--- 373

  Fly   356 SSQPFSILTLFRHNSQVEINKHVKEHIVCSADDHKMNRHHMALFVRNCRLIFLLRKNFNEGDLNI 420
                |::....:|:......|..:|.|||:...::....|.:|.|..||:.||....     |..
  Rat   374 ----FTLSFWMKHSVTPSKGKKEEETIVCNTIQNEDGYSHYSLTVHGCRIAFLYWPL-----LES 429

  Fly   421 FSPAEWRWKIPEVCDNEWHHYVLNVEDSSKVDLFIDGVRFENSIENRHSNPEVIDDWPLHAAHGV 485
            ..|.::.||:.:|||:|||||.||:|..: |.|:.||:.|:         |.:|.|..|......
  Rat   430 ARPVKFLWKLEQVCDDEWHHYALNLEFPT-VTLYTDGISFD---------PALIHDNGLIHPPRR 484

  Fly   486 NTSLAIGACYQSLENRLK-------------------HGFNGDISEVKVSLNSVLTAEDIKCGTT 531
            ..:|.||||:...:|:.|                   |.|:|.::...|....:.:.|.|:|...
  Rat   485 EPALMIGACWSEEKNKEKEKGGENSTDTTSGDPLPIHHYFHGYLAGFSVRSGRLESREVIECLYA 549

  Fly   532 CAEHLLAPKPLQSNNEKSYSD----NSQIKENIEMNEIYISAKNKHDIEQF---MRKVQYINTKQ 589
            |.|.|            .|.|    ...:|.::..::..::.:. .|:|.|   ::.|.|:||.:
  Rat   550 CREGL------------DYRDFESLGKGMKVHVNPSQSLLTLEG-DDVETFNHALQHVAYMNTLR 601

  Fly   590 KPTVGRRNIEVLTTLNC-KNESSLRLPPIETYIMVNEPIAPLGIDIDVVSASLETSDLTPPSYSP 653
            ..|.|.|.:.:.|.:.| ..||.:.:|.:|.|::|.:|.|                        |
  Rat   602 FATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDA------------------------P 642

  Fly   654 KIAISGTSN---KLVSYQEIKLGVHI---LEKTCIDSVSKN-NGKLEEK---------------N 696
            :|.:|||::   ..|.::..: ||.:   |:.||  |:|.. ..|.:|.               :
  Rat   643 QILLSGTAHFARPAVDFEGPE-GVPLFPDLQITC--SISHQVEAKADESWQGTVTDTRMSDEIVH 704

  Fly   697 HIDSCSV-VVFPSLNPDHEDIKIDGDESLSSSMDIKTNINKDGVEM---------IGKDTISNYI 751
            ::|.|.: :|...|:|:.|.:.:|           ..::.:.|:|:         .|.:||:.|.
  Rat   705 NLDGCEISLVGDDLDPERESLLLD-----------MASLQQRGLELTNRSAYLTIAGVETITVYE 758

  Fly   752 NVLRSLVYSNKKPAYYLNRVFKLSCAQQSSQYKSGEYTLTLTVLHPKQTLFKSTNVLPSSLSKVN 816
            .:||...|..:..|....|.|:|||::.:.:|.|.|:.:.:.|||....:...::||.|
  Rat   759 EILRQARYQLRHGAALYARKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSS------ 817

  Fly   817 FIGNTDNETSFHRNSGSVNGNDNNQPTESKVYSYSLLHTNNVQEPKSHIHSFIHKAEGSHVTMLI 881
                   :...||.        :..|.|...:|.:          .||.:|.:..|     ..||
  Rat   818 -------QQFLHRG--------HQPPPEMAGHSLA----------SSHRNSMVPSA-----ATLI 852

  Fly   882 ILVSVFLAVLLCGVSIARLKNNQKYI------EHHQPCPKISDDGLIWDDSALTITINPM----- 935
            |:|.|...||:..:.:.|:.:..:.:      ......||  |..|.||||||||.:|||
  Rat   853 IVVCVGFLVLMVILGLVRIHSLHRRVSGTGGPSGASADPK--DPDLFWDDSALTIIVNPMESYQN 915

  Fly   936 -QADVTSDASSESENSESEDEEVA 958
             |..|...|..:.|..:|.|.|.|
  Rat   916 QQTGVAGVAGGQQEEEDSSDSEAA 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cals	NP_001259086.1	Cadherin_repeat	45..138	CDD:206637	31/112 (28%)
		Cadherin_repeat	147..238	CDD:206637	42/91 (46%)
		LamG	<435..527	CDD:304605	30/110 (27%)
Clstn3	NP_599203.1	Cadherin_repeat	32..140	CDD:206637	31/112 (28%)
		Cadherin_repeat	150..239	CDD:206637	41/88 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..957		8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352962
Domainoid	1	1.000	250	1.000	Domainoid score	I2041
eggNOG	1	0.900	-	-		E1_KOG1834
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1784
OMA	1	1.010	-	-		QHG48981
OrthoDB	1	1.010	-	-		D155997at33208
OrthoFinder	1	1.000	-	-		FOG0001333
OrthoInspector	1	1.000	-	-		otm46441
orthoMCL	1	0.900	-	-		OOG6_103241
Panther	1	1.100	-	-	O	PTHR14139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X826
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770