DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GLR3.4

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	939	Identity:	217/939 - (23%)
Similarity:	373/939 - (39%)	Gaps:	178/939 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PPVIRVGAIFTEDE-RESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDS---FRTTKKV 100
            |..:.|||:||.|. ...:.:.|.|.|:..:|.::::|...:|    ..:.:|.:   |..|...
plant    58 PSSVNVGALFTYDSFIGRAAKPAVKAAMDDVNADQSVLKGIKL----NIIFQDSNCSGFIGTMGA 118

  Fly   101 CSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIE-GRIDLEYNSKEFSINL-------YPSHT 157
            ...:|..|.|..||..:.:|..:..:.....:|.:. |..|...:|.:|...|       :..|
plant   119 LQLMENKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLSSLQFPYFLRTTQNDYFQMH- 182

  Fly   158 LLTLAYRDIMVYLNWTKVAIIYEED----YGLFNLMHSSTETKAEMYIRQ-----ASPDSYRQVL 213
                |..|.:.|..|.:|..|:.:|    .|:..|.....:.::.:..:.     |...|.|.:|
plant   183 ----AIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGADSSSIRDLL 243

  Fly   214 RAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTF-----------DLETYDLEDF 267
            .::...|....:|..||....:.|.....|.|....|.::.|.:           |.:|.||..
plant   244 VSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAMDSMEHVDSDTMDLLQ- 307

  Fly   268 RYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFL 332
                 .:.|||...::|....:.:.:.:.|:.|  |..|      :.:...:|||:..|..|...
plant   308 -----GVVAFRHYTIESSVKRQFMARWKNLRPN--DGFN------SYAMYAYDSVWLVARALDVF 359

  Fly   333 NLDNHQNFYIK--NLSCTSDQT--------WNDGISLYNQINAAITDGLTGTVQFVEGRRNIF-K 386
            ..:|:...:..  ||..|:..|        :|:|......|......|:||.:||...|..:. .
plant   360 FRENNNITFSNDPNLHKTNGSTIQLSALSVFNEGEKFMKIILGMNHTGVTGPIQFDSDRNRVNPA 424

  Fly   387 LDILKLKQEKIQKVGYWHPDDGVNISDPTAFY----DSNIANITL--VV----MTREERPYVM-- 439
            .::|.|:....:.||||....|:::..|...|    :::.||..|  ::    :|:..|.:|.
plant   425 YEVLNLEGTAPRTVGYWSNHSGLSVVHPETLYSRPPNTSTANQRLKGIIYPGEVTKPPRGWVFPN 489

  Fly   440 ------------------VKEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYI- 485
                              |.:|||..|   ..|:|||:         |:..|||:|..:...||
plant   490 NGKPLRIGVPNRVSYTDYVSKDKNPPG---VRGYCIDV---------FEAAIELLPYPVPRTYIL 542

  Fly   486 ----PETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGIL--FKVPTSQPTR 544
                ....|::.:|.|::....|:||..:||...|...:|||:||:..|:.::  .|...|.|
plant   543 YGDGKRNPSYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVVVAPVKEAKSSP-- 605

  Fly   545 LFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFIT 609
             :||:.|..||:|......::.|...::::......|::.|           .:..:...|||..
plant   606 -WSFLKPFTIEMWAVTGGFFLFVGAMVWILEHRFNQEFRGP-----------PRRQLITIFWFSF 658

  Fly   610 GTFL---RQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQT 671
            .|..   |:    |..::..|.|...|.|..|||.|||||:|.:.||:.::.|.||....|....
plant   659 STMFFSHRE----NTVSSLGRFVLIIWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVTSN 719

  Fly   672 EISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENR-----KTAVFVKTYEDGIKRVMEGSYAFLME 731
            | ..|..:|    ||.|:           |:.|.     ...|.:|..|..:..:..|..|..:.
plant   720 E-PIGVQDG----TFARN-----------YLINELNILPSRIVPLKDEEQYLSALQRGPNAGGVA 768

  Fly   732 STM--LDY----AVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDK 790
            :.:  |.|    ....:|....:|......|:|.|..:.||....:|.|||:|.|:|.::.::.|
plant   769 AIVDELPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRK 833

  Fly   791 WWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLA--LAVVVAIFEFCWNSRKNLNTENQ 853
            |.....:...:...|::|:   |.:::..|:|  |:||:.  :|:.|..:...|        :.|
plant   834 WLNYKHECSMQISNSEDSQ---LSLKSFWGLF--LICGITCFMALTVFFWRVFW--------QYQ 885

  Fly   854 SLCSEMAEELRFAMHCHGSKSRHRPRKRS 882
            .|..|.|:|.|.......|:|....|..|
plant   886 RLLPESADEERAGEVSEPSRSGRGSRAPS 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	88/408 (22%)
		ANF_receptor	61..393	CDD:279440	76/373 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	104/415 (25%)
		Lig_chan	555..829	CDD:278489	68/287 (24%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	88/410 (21%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	25/81 (31%)
		Lig_chan	615..869	CDD:365843	69/289 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820