DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GLR1.3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	956	Identity:	186/956 - (19%)
Similarity:	340/956 - (35%)	Gaps:	218/956 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LKKIC------CSYIILSILVISNALPPV------------IRVGAIFTEDER-----ESSIESA 61
            :::.|      .|::::.:|.||.:....            ||||.:......     ::|:..|
plant     1 MERFCIQTQTLLSFLLVLLLFISRSFASTKNDDVDGGKRVQIRVGLVLDLGSLKGKIVKNSVSMA 65

  Fly    62 FKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLE----AGVQAIFGPTDALLASH 122
            ..| .|.|:.:.....:..|        |:........:.|.::    .||:||.|....|.|..
plant    66 LSY-FYAIHNDYKTRVSVSL--------RNSHGEPLLALASAVDLLKTEGVEAIIGGNSLLEAKL 121

  Fly   123 VQSICEAYDIPHIEGRIDLEYNSKEFSINLYPSHTLLTLAYRD-------IMVYLN---WTKVAI 177
            :..:.|...:|.|.  :|     ..||::| ..:|.|..|..|       |..::|   |..||:
plant   122 LGELGEKARVPMIS--LD-----SPFSLSL-SKYTHLIQATHDSTSEAKGITSFINVFDWNSVAL 178

  Fly   178 IYEEDYGLFNLMHSSTETKAEMYIR---------QASPDSYRQVLRAIRQKEIYKIIVDTNPSHI 233
            :||:.......|....|...|..:|         .:|.|.....|:.::.......:|..:....
plant   179 VYEDHDDWRESMQLLVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQLKDLGTTVFVVHLSEVIA 243

  Fly   234 KSFFRSILQLQMNDHRYHYMFTTFDLETY--DLEDFRYNSV-NITAFRLVDVDSKRYLEVINQMQ 295
            ...|....:|.:....:.::.|...:.::  :::||...:: .:..|       |.|:.:..::|
plant   244 THLFPCARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGF-------KSYIPMSIELQ 301

  Fly   296 KLQHNGLDTINGSPYIQTESALM----------FDSVYAFANGLHFLNLDNHQNFYIKNLSCTSD 350
            ..      |:.....:..|.|.:          .|..:|.|.....:.:.|          .||
plant   302 NF------TLRWRKSLPVEEAELTRLSISGIWAHDIAFALARAAEVIRMPN----------VTS- 349

  Fly   351 QTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIFKLDILKLKQEKIQKVGY------------- 402
                   :|..:|.....:||:|..|..:.:....|.:|:.:.....::||:
plant   350 -------TLLEEITKTRFNGLSGDFQLNDKKLLSNKFEIINMIGSSERRVGFLNSNGSFSNRRHL 407

  Fly   403 -----------WHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKNLTGNLRFEGFC 456
                       | |.........|:..||:...:.::|.:....|.:|..|...:|..|..||||
plant   408 SSTHNKLETIIW-PGGSAQSPKGTSLIDSDRKKLRVLVTSSNRFPRLMKVETDPVTNELIVEGFC 471

  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETN--SWNGIVQEL--MERRADLAVASMTINYARE 517
            |::.:|..:.  |.|::|         |||..|  :::.:...|  .:.:.|.||..:||...|.
plant   472 IEVFRASISP--FNYEVE---------YIPWLNGSNYDNLAYALHSQKDKYDAAVGDITITSNRS 525

  Fly   518 SVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEW 582
            :.:|||.||..:|:||:    ..:...::.|..||..::|:.....::|....::::.|....|:
plant   526 TYVDFTLPFTEMGLGIV----AVKERSMWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEF 586

  Fly   583 KNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTAN 647
            :...|         .|..:...|.|.|..:..:.   ..|...:|.|...|.|..||:.:||||.
plant   587 QGSWP---------QQIGVVLWFGFSTLVYAHRE---KLKHNLSRFVVTVWVFAVLILTASYTAT 639

  Fly   648 LAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMEN-------- 704
            |.:.:||:::  ...|..|..       |.|.|...      :.:.:.....|.|.:
plant   640 LTSMMTVQQI--RFNSNEDYV-------GHLSGSLI------ANVALTSSSLRAMRSLGLNSAAD 689

  Fly   705 ------RKTAVFVKTYEDGIKRVM-EGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATP 762
                  .||..||......:|.|: |....|.|..|      |...|           |:|....
plant   690 YAQALLNKTVSFVVDELPYLKVVLGENPTHFFMVKT------QSTTN-----------GFGFMFQ 737

  Fly   763 KGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLC 827
            ||......:|..|.:|:....:..:..:|:.|.... ..||.|     |.:.:....|:|:::..
plant   738 KGFELVPNVSREISKLRTSEKLNEMEKRWFDNQLPY-TTDDTS-----NPITLYRFRGLFIIIGV 796

  Fly   828 GLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAE-ELRFAMHCHGS 872
            ..|.|:.|.:. .|...:..:..:|..|...:.. .:.|....|.|
plant   797 SFAFALAVLVI-LCLRDKWEILVDNLDLSQRLRHFRIHFVRSIHTS 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	74/430 (17%)
		ANF_receptor	61..393	CDD:279440	66/367 (18%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	87/387 (22%)
		Lig_chan	555..829	CDD:278489	57/288 (20%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	72/409 (18%)
		ANF_receptor	57..385	CDD:279440	67/375 (18%)
		GluR_Plant	438..767	CDD:270404	86/387 (22%)
		Lig_chan	559..798	CDD:278489	57/288 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920