DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	915	Identity:	177/915 - (19%)
Similarity:	336/915 - (36%)	Gaps:	207/915 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ICCSYIILSILVISNALPPV----------IRVGAIFTEDERE-----SSIESAFKYAIYRINKE 72
            |..|::::.:..|||.....          :|||.:......|     ||:..|........|..
plant    10 ILLSFLLVLLFFISNCFASSQNNDDDKRIRVRVGLVLDLGSVEGKIVRSSVSMALSDFYDNHNDY 74

  Fly    73 KTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEA-GVQAIFGPTDALLASHVQSICEAYDIPHIE 136
            ||.|  :.||.|....|    ......|...|:. |||||.|....|.|..:..:.|...:|.|.
plant    75 KTRL--SLLVRDSHGEP----LLALDSVVDLLQTEGVQAIIGGNSLLEAKLLAELGEKARVPVIS 133

  Fly   137 GRIDLEYNSKEFSINLYPSHTLLTLAYRDIMVYL---NWTKVAIIYEEDYGLFNLMHSSTETKAE 198
            ....:..:..:::..:..:|...: ..:.|..:|   :|..||::.|:.......||...:...|
plant   134 LNSPMSLSLSKYTHLIQATHNSAS-EVKGITAFLHGFDWNSVALVLEDHDDWRESMHFMVDHFHE 197

  Fly   199 MYIR---------QASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMF 254
            ..:.         .:|.||....||.::.......:|..:.......|....:|.|....:.::.
plant   198 NNVHVQSKVAFSVTSSEDSLMDRLRELKDLGTTVFVVHLSEVIATRLFPCAEKLGMMGEGFAWIL 262

  Fly   255 TTFDLETYD---LEDFRYNSV-NITAFRLVDVDSKRYLEVINQMQKLQHN---------GLDTIN 306
            |:..:.::.   ::|....:: .:..|       |.|:    .|.|..||         .::.:.
plant   263 TSRSMSSFHDQFIDDLTKEAMEGVVGF-------KSYI----PMSKELHNFTLRWRKTLPVEEVT 316

  Fly   307 GSPY--IQTESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITD 369
            ||..  :........|..::.|:......:.          :.||        :|...|..:...
plant   317 GSEITRLSISGVWAHDVAWSLASAAEVTRMP----------TVTS--------TLLEAIKESRFK 363

  Fly   370 GLTGTVQFVEGRRNIFKLDILKLKQEKIQ----------KVGYWHPD------------------ 406
            ||:|.          |:||.:||..:|.:          :||:|:.:
plant   364 GLSGN----------FQLDDMKLLSDKFEIVNMIGSGERRVGFWNSNGSFSNRRQLSSTHDNLET 418

  Fly   407 ---DGVNISDP--TAFYDSNIANITLVVMTREERPYVMVKEDKNLTGNLRF-EGFCIDLLKA-IA 464
               .|.:...|  .:..:|....:.::|.:....|.:|..|...:|..:.. |||||::.:| ||
plant   419 IIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNRFPRLMKVETDPITHEITIVEGFCIEVFQASIA 483

  Fly   465 TQVGFQYKIELVPDNMYGVYIPETNSWN----GIVQELMERRADLAVASMTINYARESVIDFTKP 525
            .   |.|::|         ||...|..|    .......:.:.|.||..:||...|...:|||.|
plant   484 P---FNYEVE---------YIRWLNGTNYTKLAYALHSQKDKYDAAVGDITITSDRSMYVDFTLP 536

  Fly   526 FMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYK 590
            :..:|:||:    .::...::.|..||...:|:...|.::|....::::.|....|::...|  :
plant   537 YTEMGLGIV----AAKERSMWVFFQPLTPNLWITSAAFFVLTGIIVWLIERAENKEFQGSWP--Q 595

  Fly   591 ETDIVENQFSISNSFWFITGTFL---RQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFL 652
            :..:|         .||...|.:   |:....|    .:|.|...|.|..||:::||||.|.:.:
plant   596 QIGVV---------IWFGFSTLVYAHREKLQHN----LSRFVVTVWVFAVLILVTSYTATLTSMM 647

  Fly   653 TVERMISPIESASDLAEQTEISY--GTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYE 715
            ||:::       ...|.:..:.:  |:|...:.:|   :|.:       |.|.    .:.:.|.|
plant   648 TVQQI-------RFNANEDYVGHLSGSLIANAALT---NSSL-------RAMR----LLGLNTSE 691

  Fly   716 DGIKRVMEGSYAFLMESTMLDYAV----QRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAIL 776
            |..:.:|..|.::::..  |.|..    :...:...:.....:.|:|....|||.....:|..|.
plant   692 DYAQALMNKSVSYIVSE--LPYLKILLGENPGHFLMVKTQSTTNGFGFMFQKGSELAPNVSREIA 754

  Fly   777 ELQEKGIIQILYDKWWKNTGDVCNRDDK----SKESKANALGVENIGGVFVVLLCGLALAVVVAI 837
            :|:....:..:..:|:          ||    :.:..:|.:.:....|:|  ::.|::.|..:|:
plant   755 KLRTSERLNEMERRWF----------DKQLPYTTDDTSNPITLYRFRGLF--MITGVSFAFALAV 807

  Fly   838 FEFCW 842
            ....|
plant   808 LLILW 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	77/429 (18%)
		ANF_receptor	61..393	CDD:279440	65/359 (18%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	84/383 (22%)
		Lig_chan	555..829	CDD:278489	53/286 (19%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	76/411 (18%)
		ANF_receptor	55..387	CDD:279440	69/377 (18%)
		GluR_Plant	440..770	CDD:270404	83/383 (22%)
		Lig_chan	563..801	CDD:278489	54/287 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920