DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GLR2.1

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	877	Identity:	177/877 - (20%)
Similarity:	329/877 - (37%)	Gaps:	190/877 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYPSHTLLTLAY--------- 163
            |:||.||..::.|..:..:.:...:|.:      .|::...|:....|.......|
plant    97 VKAILGPWTSMQAQFMIEMGQKSQVPIV------TYSATSPSLASIRSQYFFRATYDDSSQVHAI 155

  Fly   164 RDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMYIRQASPDSYRQVLRAIRQKEIYKIIVD- 227
            ::|:....|.:||.:|.:|.....:|...|:...|:.:|    ..||.|:......:  :|.|:
plant   156 KEIIKLFGWREVAPVYVDDTFGEGIMPRLTDVLQEINVR----IPYRTVISPNATDD--EISVEL 214

  Fly   228 ----TNPSHI----------KSFFRSILQLQMNDHRYHYMFT--------------------TFD 258
                |.|:.:          ..||....::.:....|.::.|                    ...
plant   215 LRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYVWILTNTITDVLSIMNETEIETMQGVLG 279

  Fly   259 LETY-----DLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALM 318
            ::||     :||:||...            :||:     .:..|...||...:.:    |..||.
plant   280 VKTYVPRSKELENFRSRW------------TKRF-----PISDLNVYGLWAYDAT----TALALA 323

  Fly   319 FDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRN 383
            .:.  |..:.|.|:.:|..:|  :..|.......:  |..|...::.....||.|..||:.|...
plant   324 IEE--AGTSNLTFVKMDAKRN--VSELQGLGVSQY--GPKLLQTLSRVRFQGLAGDFQFINGELQ 382

  Fly   384 IFKLDILKLKQEKIQKVGYWHPDDGV--NISDPTAFYDSNIANITLVVMTREERPYV-------- 438
            ....:|:.:..:..:.:|:|..:.|:  |:....|      :..|........||.:
plant   383 PSVFEIVNVNGQGGRTIGFWMKEYGLFKNVDQKPA------SKTTFSSWQDRLRPIIWPGDTTSV 441

  Fly   439 -------------------------MVKEDKN-LTGNLRFEGFCIDLLKAIATQVGFQYKIELVP 477
                                     .||..:: :|.:..|.||.||..:|:         |:.:|
plant   442 PKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAV---------IQAIP 497

  Fly   478 DNMYGVYIP-ETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQ 541
            .::...:|| :...::.:|.::...:.|..||..||:..|...:||:.|:...|:|::  ||...
plant   498 YDISYDFIPFQDGGYDALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLV--VPVKD 560

  Fly   542 PTRLFS--FMNPLAIEIWLYVLAAYILVSFALFVMA-RFSPYEWKNPHPCYKETDIVENQFSISN 603
            ..|..|  |:.||.:.:||..|.::.::...::|:. |.:| ::..|           .|:.:|.
plant   561 SVRRSSTIFLMPLTLALWLISLLSFFIIGLVVWVLEHRVNP-DFDGP-----------GQYQLST 613

  Fly   604 SFWFITGTFLRQGSGLNPKATS--TRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASD 666
            .|||   :|.........:..|  .|:|...|:|..|::..||||:||:.||.:.:...:.:.:.
plant   614 IFWF---SFSIMVFAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINS 675

  Fly   667 -LAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLM 730
             ||:...:.|   :....:...|||.......:.........|:..|...:|      |..|.||
plant   676 LLAKGESVGY---QSSFILGRLRDSGFSEASLVSYGSPEHCDALLSKGQAEG------GVSAVLM 731

  Fly   731 ESTMLDYAVQRDCN---LTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWW 792
            |...:...:.:.||   :.|....:|  |.|...|.|||....||.|||:::|......|.:.|:
plant   732 EVPYVRIFLGQYCNKYKMVQTPFKVD--GLGFVFPIGSPLVADISRAILKVEESNKANQLENAWF 794

  Fly   793 KNTGDVC----NRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQ 853
            |...:.|    ...|.:.......||.::...:|:|......:|::..:::|.   ::|.|..|.
plant   795 KPIDESCPDPLTNPDPNPSVSFRQLGFDSFWVLFLVAAIVCTMALLKFVYQFL---KENPNQRNL 856

  Fly   854 SLCSEMAEE------LRFAMHCHGSKSRHRPR 879
            .:..|...|      ::....|..|..:..|:
plant   857 RVLWEKFNEPDQKSYIKDVTKCQCSSGQGMPK 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	64/352 (18%)
		ANF_receptor	61..393	CDD:279440	61/333 (18%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	94/412 (23%)
		Lig_chan	555..829	CDD:278489	66/284 (23%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	64/352 (18%)
		ANF_receptor	49..392	CDD:279440	61/333 (18%)
		GluR_Plant	452..794	CDD:270404	90/378 (24%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	58/232 (25%)
		Lig_chan	576..835	CDD:278489	66/284 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920