DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GLR2.4

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001328410.1	Gene:	GLR2.4 / 829299	AraportID:	AT4G31710	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	833	Identity:	181/833 - (21%)
Similarity:	305/833 - (36%)	Gaps:	176/833 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VQAIFGPTDALLASHVQSICEAYDIPHI----------EGRIDLEYNSKEFSINLYPSHTLLTLA 162
            |:||.||...:.||.|..:.:...:|.|          .||      |..|..:.|...:.:. |
plant   120 VKAILGPRTTMQASFVIEVGQKSQVPIISFSATSPFLDSGR------SPYFFRSTYDDSSQVQ-A 177

  Fly   163 YRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMYIR---------QASPDSYRQVLRAIRQ 218
            ..:|:....|.:|..:||.:.....:|...|:....:.||         .|:.|.....|..:..
plant   178 ISEIIKVFGWREVVPVYENNAFGEGIMPGLTDALQAINIRIPYRTVISPNATDDEISVDLLKLMT 242

  Fly   219 KEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDVD 283
            |.....:|..|.......|....:..:....|.::.|...::...|    .|..:|.|.:.| :.
plant   243 KPTRVFVVHMNRFLASRVFSKARETGLMKQGYAWILTNGVIDHLVL----MNGTDIEAMQGV-IG 302

  Fly   284 SKRYLEVINQMQKLQHN-----GLDTIN--GSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFY 341
            .:.:..:..::|..:..     .:..:|  |.......:||......|....|.|..:|...
plant   303 IRTHFPISEELQTFRSRLAKAFPVSELNIYGLRAYDATTALAMAVEEAGTTNLTFSKMDGRN--- 364

  Fly   342 IKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIFKLDILKLKQEKIQKVGYWHPD 406
            |.:|...|...:  |..|...::.....||:|...||:|:.:....:|:.:.......||:|..|
plant   365 ISDLEALSVSEY--GPKLIRSLSQIQFKGLSGDYHFVDGQLHASVFEIVNVIDGGGILVGFWTQD 427

  Fly   407 DGV-----NISDPTAFYDS--NIAN------ITLVVMTREERP-----------------YVMVK 441
            .|:     ..|..|..:.|  |..|      |||.|....|.|                 :|.|.
plant   428 KGLVKDLSPSSGTTRTFSSWKNHLNPILWPGITLTVPKGWEIPTNGKELQIGVPVGTFPQFVKVT 492

  Fly   442 EDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIP------ETNSWNGIVQELME 500
            .|. ||......|||||..:|:         |:.:|.::...:||      :||
plant   493 TDP-LTHETIVTGFCIDFFEAV---------IQAMPYDVSHRFIPFGDDDGKTN----------- 536

  Fly   501 RRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYI 565
                    ..||...|.|.:|||.|:...|:|::..:..:.......|..||...:|...|.::.
plant   537 --------DTTILANRSSYVDFTLPYTTSGVGMVVPLKDNVARSSLIFFKPLTPGLWGMTLGSFF 593

  Fly   566 LVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPK----ATST 626
            :|.|.::::......|:..|           .|:.||..|||.....:     ..|:    :.:.
plant   594 VVGFVVWILEHRVNSEFTGP-----------PQYQISTMFWFAFSIMV-----FAPRERVMSFTA 642

  Fly   627 RIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESA--SDLAEQTEISY-------GTL-EGG 681
            |:|...|:|..|::..||||:|::.||.:: ::|.|::  :.||:...::|       |.| |.|
plant   643 RVVVITWYFIVLVLTQSYTASLSSLLTTQQ-LNPTETSIKNVLAKGGPVAYQRDSFVLGKLRESG 706

  Fly   682 STMTFFRDSKIGIYQKMWRYME--NR---KTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQR 741
                 |.:|::..:....:..|  |:   |..|.....|....||..|.|....:...:.:
plant   707 -----FPESRLVPFTSPEKCEELLNKGPSKGGVSAAFMEVPYVRVFLGQYCKKYKMVEVPF---- 762

  Fly   742 DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVC----NRD 802
                       |..|:|...|.|||....:|.|||::.|......|...|:||....|    |..
plant   763 -----------DVDGFGFVFPIGSPLVADVSRAILKVAESNKATQLETAWFKNIDKTCPDPMNNP 816

  Fly   803 DKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEF--CW--NSRKNLNTE 851
            |.:.......|.:::    |::|....|....:|:.:|  |:  .:|..||.|
plant   817 DPNPTVSFRKLSLDS----FLLLFVAAATVCTLALLKFVICFLIQNRIILNDE 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	65/332 (20%)
		ANF_receptor	61..393	CDD:279440	60/310 (19%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	96/416 (23%)
		Lig_chan	555..829	CDD:278489	67/296 (23%)
GLR2.4	NP_001328410.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920