DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GLR2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	972	Identity:	218/972 - (22%)
Similarity:	400/972 - (41%)	Gaps:	170/972 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SYIILSILVI-----------SNALPPVIRVGAIF---TEDERESSIESAFKYAIYRINKEKTLL 76
            ::::||.:::           |::.||||:|||||   |.....::|  |||.|...:|.:.:.|
plant     6 NWVLLSFIIVLGGGLLLSEGASSSRPPVIKVGAIFGLNTMYGETANI--AFKAAEEDVNSDPSFL 68

  Fly    77 PNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIE-GRID 140
            ..::|...:....| ..|.:.......:|..|.||.||..:::|..:..:.....:|.:. ..:|
plant    69 GGSKLRILMNDAKR-SGFLSIMGALQFMETDVVAIIGPQTSIMAHVLSHLANELTVPMLSFTALD 132

  Fly   141 LEYNSKEFS--INLYPSHTLLTLAYRDIMVYLNWTKVAIIYEED----YGLFNLMHSSTETKAEM 199
            ...:..:|.  :...||...|..|..:::.|..|:.|..:|.:|    .|:..|.....|.:.::
plant   133 PTLSPLQFPFFVQTAPSDLFLMRAIAEMITYYGWSDVVALYNDDDNSRNGVTALGDELEERRCKI 197

  Fly   200 YIRQ--------ASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTT 256
            ..:.        .||....:.|..||..|...|:|:|.|:..|..|:...:|.|.:..|.::.||
plant   198 SYKAVLPLDVVITSPVEIIEELIKIRGMESRVIVVNTFPNTGKMIFKEAERLGMMEKGYVWIATT 262

  Fly   257 FDLETYD----LEDFRYNSVNITAFRLVDVDSKRYLEVINQMQ-KLQHNGLDTINGSPYIQTESA 316
            :.....|    |:....|.|  ...||...||::..:...:.: ||.:|  .||..:.|    ..
plant   263 WLSSVLDSNLPLDTKLVNGV--LTLRLHTPDSRKKRDFAARWKNKLSNN--KTIGLNVY----GL 319

  Fly   317 LMFDSVYAFANGLHFLNLDNHQNFYIKN-----------LSCTSDQTWNDGISLYNQINAAITDG 370
            ..:|:|:..|..:..| |:...|....|           |:.::...::.|..|.:.|......|
plant   320 YAYDTVWIIARAVKTL-LEAGGNLSFSNDAKLGSLKGEALNLSALSRFDQGSQLLDYIVHTKMSG 383

  Fly   371 LTGTVQFVEGRRNIF-KLDILKLKQEKIQKVGYWHPDDGVNISDPTAFY---------DSNIANI 425
            |||.|||...|..:. ..||:.|..:::.::|||....|::|..|.:||         :.::.::
plant   384 LTGPVQFHPDRSMLQPSYDIINLVDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSV 448

  Fly   426 TLVVMTR-EERPYVMVKEDKNLT------------------GNLRFEGFCIDLLKAIATQVGFQY 471
            |....|. ..|.::.....:.|.                  .:.:.:|:|||:.:|....:.:..
plant   449 TWPGGTSVTPRGWIFRNNGRRLRIGVPDRASFKDFVSRVNGSSNKVQGYCIDVFEAAVKLLSYPV 513

  Fly   472 KIELVPDNMYGVYIPETNSWNGIVQELMER-RADLAVASMTINYARESVIDFTKPFMNLGIGILF 535
            ..|.:   .:|..:...| :|.:|.::... ..|..|..:.|...|..::|||:|::..|:.::.
plant   514 PHEFI---FFGDGLTNPN-YNELVNKVTTGVDFDAVVGDIAIVTKRTRIVDFTQPYIESGLVVVA 574

  Fly   536 KVPTSQPTRL----FSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVE 596
            .|     |||    ::|:.|..:.:|....:.:::|..|::::......|::.|
plant   575 PV-----TRLNENPWAFLRPFTLPMWAVTASFFVIVGAAIWILEHRINDEFRGP----------- 623

  Fly   597 NQFSISNSFWFITGTFL---RQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMI 658
            .:..|....||...|..   |:    ...:|..|:|...|.|..|||.|||||:|.:.|||:::.
plant   624 PRRQIITILWFTFSTMFFSHRE----TTVSTLGRMVLLIWLFVVLIITSSYTASLTSILTVQQLN 684

  Fly   659 SPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKT---------AVFVKTY 714
            |||:....|...|                  .:||.  ::..:.||..|         .|.:.:.
plant   685 SPIKGVDTLISST------------------GRIGF--QVGSFAENYMTDELNIASSRLVPLASP 729

  Fly   715 EDGIKRVMEGSYAFLM-ESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILEL 778
            |:....:..|:.|.:: |...:|..:...|.....|......|:|.|.|:.||....:|.|||.|
plant   730 EEYANALQNGTVAAIVDERPYIDLFLSDYCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGL 794

  Fly   779 QEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIF----- 838
            .|.|.:|.::|:|...:.  |:....|:...:..|.|.:..|:|:|    :.:|.:||:|
plant   795 SETGELQKIHDRWLSKSN--CSSPHGSQSGDSEQLNVHSFWGMFLV----VGIACLVALFIHFFK 853

  Fly   839 ---EFCWNS-----RKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRS---CLNCSSV 889
               :||.::     .:.:.:...|..:::...|.|.........|...|||:   .:|.:|:
plant   854 IIRDFCKDTPEVVVEEAIPSPKSSRLTKLQTFLAFVDEKEEETKRRLKRKRNNDHSMNANSI 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	95/400 (24%)
		ANF_receptor	61..393	CDD:279440	83/363 (23%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	90/405 (22%)
		Lig_chan	555..829	CDD:278489	68/286 (24%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	95/400 (24%)
		GluR_Plant	468..808	CDD:270404	86/383 (22%)
		Lig_chan	594..843	CDD:306551	68/289 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I1601
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870