DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11155 and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	442	Identity:	164/442 - (37%)
Similarity:	257/442 - (58%)	Gaps:	27/442 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 LVVMTREERPYVMVKEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSW 491
            |.|.|.:|.||.|.|..:       .||||||:|.||:.::||:|.:.||.|..|| ...::.:|
Zfish    25 LKVTTIKEEPYAMSKGSE-------LEGFCIDMLSAISNKLGFKYDVHLVKDGRYG-KTDDSGNW 81

  Fly   492 NGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIG-ILFKVPTSQPTRLFSFMNPLAIE 555
            ||::.|::...||:|||.:|:...||:|:|.:||||..|:. |:.|...|..::..|.:...:.|
Zfish    82 NGMIGEVVRGEADIAVAPLTLTAQREAVVDMSKPFMQTGLSFIMRKDLGSDDSQFLSLLKLFSTE 146

  Fly   556 IWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLN 620
            :|:.||.||:|.|..:|:::|.||.||:.|     |.|  .|.|::|:|||:..|....||:|.:
Zfish   147 MWMGVLVAYLLTSICIFLVSRISPCEWEQP-----EKD--NNSFTLSHSFWYTVGALTLQGAGPH 204

  Fly   621 PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMT 685
            |||.|.|::...|:.|.|::::.|.|||:.:|..:.....|::..|||.|..|.|||::..|:..
Zfish   205 PKALSGRVITSIWWIFSLVLLACYFANLSLWLHSDNQQLSIKTFEDLANQNVIEYGTIKDSSSFN 269

  Fly   686 FFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGG 750
            ||::|....|.:::.:::..::  :.....:|.:|..:|:|||:.||..||.||.|.||||:...
Zfish   270 FFKNSNNPTYHRIYEHIKEAQS--YSLNAAEGFRRAQKGNYAFIGESVSLDLAVARYCNLTRAPE 332

  Fly   751 LLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGV 815
            ::..:||.||.|.|||....:|:|||.|.|.|.:.....|||.::   |    .:|:||...|..
Zfish   333 IIGMRGYSIAAPLGSPLIKNLSVAILRLSESGELDYFRSKWWASS---C----VAKDSKGAPLKP 390

  Fly   816 ENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEEL--RF 865
            .::.|||::|..||.|.:.:|:.|....|||..|:|.:|.||.|:.||  ||
Zfish   391 ASLKGVFLLLAFGLGLGIFLALMELAAKSRKVANSEQKSCCSVMSAELSQRF 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377
		ANF_receptor	61..393	CDD:279440
		PBP2_iGluR_Kainate	424..793	CDD:270432	136/366 (37%)
		Lig_chan	555..829	CDD:278489	98/273 (36%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	136/366 (37%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	94/265 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910