DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11155 and grik2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	883	Identity:	395/883 - (44%)
Similarity:	572/883 - (64%)	Gaps:	52/883 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IILSILVI--SNALPPVIRVGAIFTEDERESSIES--------AFKYAIYRINKEKTLLPNTQLV 82
            ::|.:|.:  |:.:|.|:|.|.||      .||||        |||:|:..||:.:||||||.|.
Zfish    19 LLLLLLCVGYSHGMPHVLRFGGIF------ESIESGPSGAEELAFKFALNTINRNRTLLPNTTLT 77

  Fly    83 YDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIE--GRIDLEYNS 145
            |||:.:...|||..::|.|.||..||.|||||:.:..|:.|||||.|..:|||:  .:..:..|.
Zfish    78 YDIQRINIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNR 142

  Fly   146 KEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLF---NLMHSSTETKAEMYIRQASPD 207
            ..|.:||||..:.|:.|..|::.:..|..|.::|::..||.   .|:.:.:.....:.|||...|
Zfish   143 DSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQLPAD 207

  Fly   208 S--YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYN 270
            :  .:.:|:.:::.:.:.:|.|..........:..|.:.|....|||:|||.||...|:|.:||:
Zfish   208 TKDAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYS 272

  Fly   271 SVNITAFRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAFANG 328
            .||:|.||:::.::.:...:|.:  |::||     .:||  ::|  ::.|::|||:|:|:..|
Zfish   273 GVNMTGFRILNTENSQVSSIIEKWSMERLQAPPKPDSGL--LDG--FMTTDAALMYDAVHVVA-- 331

  Fly   329 LHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFKLDILK 391
               :.:.......:.:|.|...:.|..|......|..|..|||||.:.|  ..|.|..|.||::.
Zfish   332 ---VAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVIS 393

  Fly   392 LKQEKIQKVGYWHPDDGVNISD----PTAFYDSNIANITLVVMTREERPYVMVKE-DKNLTGNLR 451
            ||:|.::|:|.|.|..|:|:::    .||....:::|.:|||.|..|.||||.|: ||.|.||.|
Zfish   394 LKEEGLEKIGTWDPASGLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDR 458

  Fly   452 FEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYAR 516
            |||:|:|||:.:|..:||.|::.||.|..||.....:..|||:|:|||:.:||||||.:.|.|.|
Zfish   459 FEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVR 523

  Fly   517 ESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYE 581
            |.||||:||||.|||.||::.|......:|||:|||:.:||:|:|.||:.||..|||:|||||||
Zfish   524 EKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYE 588

  Fly   582 WKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTA 646
            |.|||||..::|:|||.|::.|||||..|..::|||.|.|||.|||||||.|:||.|||||||||
Zfish   589 WYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653

  Fly   647 NLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFV 711
            |||||||||||.|||:||.|||:||:|.||.:|.|||||||:.:||..|.|||.:|.:|:.:|.|
Zfish   654 NLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMV 718

  Fly   712 KTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAIL 776
            |:.|:||:||:...||||||||.:::..||:|||||||||:|||.||:.||.|||:||||::|||
Zfish   719 KSIEEGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAIL 783

  Fly   777 ELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFC 841
            :|||:|.:.::.:|||:..|  | .::::||  |:||||:||||:|:||..||.|:|.||:.||.
Zfish   784 QLQEEGKLHMMKEKWWRGNG--C-PEEENKE--ASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843

  Fly   842 WNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPR 879
            :.|::|...|.:|.||.|.:|||.::.|. .:.:|:|:
Zfish   844 YKSKQNAQLEKRSFCSAMVDELRVSLKCQ-RRLKHKPQ 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	128/389 (33%)
		ANF_receptor	61..393	CDD:279440	112/347 (32%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	221/369 (60%)
		Lig_chan	555..829	CDD:278489	168/273 (62%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	129/391 (33%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	221/369 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591863
Domainoid	1	1.000	359	1.000	Domainoid score	I916
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860