DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and gria4a

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	910	Identity:	337/910 - (37%)
Similarity:	495/910 - (54%)	Gaps:	83/910 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSILVI--------SNALPPVIRVGAIF---TEDERESSIESAFKYAIYRINKEKTLLPNT---- 79
            :.|||:        ..|.|..:::|.:|   |:.|     .:||:.||:..|..    ||.
Zfish     1 MRILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQE-----YTAFRLAIFLHNTS----PNATEAP 56

  Fly    80 -QLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEY 143
             .||..::.:...:||..|...|||...||.||||..|......:.|.|.|..|..:......|
Zfish    57 FNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAE- 120

  Fly   144 NSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAE-------MYI 201
            ...:|.:.|.||   :..|...::.:.:|::...:|:.|.| :.::.:..|...:       :.:
Zfish   121 GETQFVLQLRPS---IRGALLSLLDHYDWSRFVFLYDTDRG-YAVLQAIMEKAGQNGWQVSAICV 181

  Fly   202 RQASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLED 266
            ...:..|||::|..:.:::..|.::|.....:::....|:.:..:...|||:......:...||.
Zfish   182 ENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLER 246

  Fly   267 FRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHF 331
            |.:...|:|.|:|||......::::.:..||...........|  :..|:|.:|.|...|..  |
Zfish   247 FMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPP--RYTSSLTYDGVLVMAEA--F 307

  Fly   332 LNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDI 389
            .|| ..|...|.......|      ..||.||.:...:......||||.:||.. |||..:.:|:
Zfish   308 RNL-RRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDV 371

  Fly   390 LKLKQEKIQKVGYWHPDDGVNI--SDPTAFYDSNIANITLVVMTREERPYVMVKEDKNL-TGNLR 451
            .:||....:|:|||:..|.:.:  ::.:...||.:.|.|::|.|..|.||||:|::..: .||.:
Zfish   372 FELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQ 436

  Fly   452 FEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYAR 516
            |||:|:||...:|..:|.:|||.:|.|..||...|||..|||:|.||:..:|::|||.:.|...|
Zfish   437 FEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVR 501

  Fly   517 ESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYE 581
            |.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::||||||
Zfish   502 EEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 566

  Fly   582 WKNPHPCYKE------TDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLII 640
            |....|  :|      :|...|:|.|.||.||..|.|::||....|::.|.|||||.|:||.|||
Zfish   567 WHTEEP--EEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLII 629

  Fly   641 ISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENR 705
            |||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.||::.
Zfish   630 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 694

  Fly   706 KTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPW 767
            :..||.||..:|:.||  .:|.||||:||||.:|..|| .|:..::||.|||||||:||||||..
Zfish   695 EPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQL 759

  Fly   768 RDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALA 832
            ...::||:|:|.|.|::..|.:|||.:.|:...:|..||:..:.||.:.|:.|||.:|:.||.||
Zfish   760 GTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLA 824

  Fly   833 VVVAIFEFCWNSR---KNL---------NTENQSLCSEMAEELRF-------AMHCHGSKSRHRP 878
            ::||:.|||:.||   |.|         |....|:...:.|..|.       |:| .|...||.|
Zfish   825 MLVALVEFCYKSRAEAKKLKLTFSEAMRNKARLSITGSLGENGRVLTPDCPKAVH-SGPSYRHGP 888

Fly 879 878
Zfish 889 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	95/387 (25%)
		ANF_receptor	61..393	CDD:279440	84/350 (24%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	200/378 (53%)
		Lig_chan	555..829	CDD:278489	149/282 (53%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	95/388 (24%)
		ANF_receptor	34..375	CDD:279440	85/359 (24%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	202/383 (53%)
		Lig_chan	540..821	CDD:278489	149/282 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750