DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and gria3b

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	923	Identity:	334/923 - (36%)
Similarity:	503/923 - (54%)	Gaps:	89/923 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SYIILSILVISNAL---PPVIRVGAIFTEDERESSIE--SAFKYAI--YRINKEKTLLPNTQLVY 83
            |.:|..:.:...:|   |..|.:|.:|    ..|:::  |||::|:  |..|:..|..| ..|.|
Zfish     4 SALIFLLWLFGTSLAGFPNQINIGGLF----MRSTVQEHSAFRFAVQLYNTNQNMTEKP-FHLNY 63

  Fly    84 DIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEF 148
            :::.:...:||..|...|||...||.||||..|....:.:.|.|.|.....:.....:: :..:|
Zfish    64 NVDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDKKSMNTLTSFCGALHTSFVTPSYPID-SDVQF 127

  Fly   149 SINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---LFNLMHSSTETKAEMYIRQ----ASP 206
            .|.:.|.   |..|...::.:..|.|...:|:.|.|   |..:|.::.....::..|.    ..|
Zfish   128 VIQMRPP---LKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVANNWQVTARSVGSITDP 189

  Fly   207 DSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNS 271
            ..:|:::..:.:::..:.::|.....|......::.|..|...|||:..........|:......
Zfish   190 QEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRGYHYIIANLGFTNISLDKVFLGG 254

  Fly   272 VNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDN 336
            .||:.|::::.::....:.:.:..:|..........:| ::..|||.:|::...|....:|   .
Zfish   255 ANISGFQIINPENLVVQQFLQRWDRLDEREFPEAKNTP-LKYTSALSYDAILVIAEAFRYL---R 315

  Fly   337 HQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQ 394
            .|...:.......|      ..|:.||.:...:......|:||.:||.. |||..:.:|:.::|.
Zfish   316 RQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKT 380

  Fly   395 EKIQKVGYWHP-DDGVNISDPTAFYD-SNIANITLVVMTREERPYVMVKED-KNLTGNLRFEGFC 456
            ...:|:|||:. :..|||.|.....| |::.|.|:||.|..|.||||.|:: .:|.||.::||:|
Zfish   381 GGPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKKNHMHLEGNEKYEGYC 445

  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVID 521
            :||...||..||.:|::.:|.|..||...|||.||||:|.||:..|||:|||.:||...||.|||
Zfish   446 VDLASEIAKHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVAPLTITLVREEVID 510

  Fly   522 FTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPH 586
            |:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||:
Zfish   511 FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWQ--- 572

  Fly   587 PCYKETDIVE---------NQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIIS 642
              ..|||.|:         |.|.|.||.||..|.|::||..::|::.|.|||||.|:||.|||||
Zfish   573 --LDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIIS 635

  Fly   643 SYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKT 707
            |||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.||::.:.
Zfish   636 SYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEP 700

  Fly   708 AVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRD 769
            :||.||..||:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:||||||..|:
Zfish   701 SVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRN 765

  Fly   770 KISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVV 834
            .::||:|:|.|:|::..|.:|||.:.|: |.......:.|.:||.:.|:.|||.:|:.||.||::
Zfish   766 AVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMM 829

  Fly   835 VAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVPTYVPSNVST 899
            ||:.|||:.||              ||..|..:            :::..|....|   |:|  |
Zfish   830 VALIEFCYKSR--------------AEAKRLKL------------EKNAQNYKPAP---PAN--T 863

  Fly   900 SNVGVY---YNYF 909
            .|...|   ||.:
Zfish   864 QNFATYREGYNVY 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	82/384 (21%)
		ANF_receptor	61..393	CDD:279440	73/347 (21%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	207/381 (54%)
		Lig_chan	555..829	CDD:278489	150/285 (53%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	82/383 (21%)
		ANF_receptor	36..379	CDD:279440	74/351 (21%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	209/387 (54%)
		Lig_chan	544..824	CDD:278489	150/285 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650