DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Ir40a

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	115/539 - (21%)
Similarity:	192/539 - (35%)	Gaps:	124/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 WHPDDGVNISD----PTAF--YDSNIANITLVVMTREERPYVMV-------KEDK---------- 444
            |:..|.:.:..    |||.  | :|....|..|......|:..|       :||:
  Fly   189 WYDGDNLGLQRIPLLPTALSVY-ANFKGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEK 252

  Fly   445 ---NLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPE-----TNSWNGIVQELMER 501
               .:||     |....||..::..:.|::|....|....|....|     .:|:.|.:..|...
  Fly   253 RKVRVTG-----GRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSG 312

  Fly   502 RADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRL---FSFMNPLAIEIWLYVLAA 563
            :||..:..:.:::.|...|:|:  |..|.....|  .|..|.||   .:.|.|...:||.:::..
  Fly   313 QADFFLGDVGLSWERRKAIEFS--FFTLADSGAF--ATHAPRRLNEALAIMRPFKQDIWPHLILT 373

  Fly   564 YILVSFALFVMARFSPYEWKNP--------------HPCY-KE-----------TDIVENQFS-- 600
             |:.|..:|......||.|:..              |..| ||           |.:..:|..
  Fly   374 -IIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQ 437

  Fly   601 -ISNSFWFITGTFLRQG-----SGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMIS 659
             .....||....||:|.     :|...|..:  ||  .|.....::...|:|.|.:.........
  Fly   438 LFQKCIWFTLRLFLKQSCNELHNGYRAKFLT--IV--YWIAATYVLADVYSAQLTSQFARPAREP 498

  Fly   660 PIESASDL------------AEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVK 712
            ||.:...|            .|:...|...||.|:.:  ||.    :|..|.:.:.|.....|:.
  Fly   499 PINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTEL--FRQ----LYALMRQQVINDPQGFFID 557

  Fly   713 TYEDGIKRVMEG--SYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLA 774
            :.|.|||.:.||  ..|.|.....|.:.||: ..|..|:...|.::...:|...|.|:...::..
  Fly   558 SVEAGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNV 622

  Fly   775 ILELQEKGIIQIL----YDKWW---------------KNTGDVCNRDDKSKESKANALGVENIGG 820
            :::|.|.||:..:    |.|.:               ||: :..:|.:....:..:.|.:..:.|
  Fly   623 LMQLFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNS-EAYSRTESYDSTVISPLNLRMLQG 686

  Fly   821 VFVVLLCGLALAVVVAIFE 839
            .|:.|..|...|.|:.:.|
  Fly   687 AFIALGVGSLAAGVILLLE 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	2/6 (33%)
		ANF_receptor	61..393	CDD:279440
		PBP2_iGluR_Kainate	424..793	CDD:270432	97/464 (21%)
		Lig_chan	555..829	CDD:278489	71/341 (21%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	25/128 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	24/98 (24%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	35/146 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840