back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Gria3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001106213.1	Gene:	Gria3 / 29628	RGDID:	70958	Length:	888	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	329/877 - (37%)
Similarity:	492/877 - (56%)	Gaps:	59/877 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GRSYLKKICCSYIILSILVISN-ALPPVIRVGAIFTEDERESSIESAFKYAI--YRINKEKTLLP 77
            |:|.|:.:  .:::|.:|..|: ..|..|.:|.:|..:..:.  .|||::|:  |..|:..|..|
  Rat     2 GQSVLRAV--FFLVLGLLGHSHGGFPNTISIGGLFMRNTVQE--HSAFRFAVQLYNTNQNTTEKP 62

  Fly    78 NTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEA----YDIPHIEGR 138
             ..|.|.::::...:||..|...|||...||.||||..|.:..:.:.|.|.|    :..|.....
  Rat    63 -FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD 126

  Fly   139 IDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---LFNLMHSSTETKAEMY 200
            .|:     :|.|.:.|:   |..|...::.|..|.|...:|:.:.|   |..:|.::.:...::.
  Rat   127 ADV-----QFVIQMRPA---LKGAILSLLGYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVT 183

  Fly   201 IRQA----SPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLET 261
            .|..    ....:|:::..:.:::..:.::|.....|.:....::.|..:...||||........
  Rat   184 ARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTD 248

  Fly   262 YDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFA 326
            ..||...:...|||.|::|:.::....:.|.:..:|..........:| ::..|||..|::...|
  Rat   249 ILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAP-LKYTSALTHDAILVIA 312

  Fly   327 NGLHFLNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNI 384
            ....:|   ..|...:.......|      ..|:.||.:...:......|:||.:|| ..|||..
  Rat   313 EAFRYL---RRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTN 374

  Fly   385 FKLDILKLKQEKIQKVGYWHP-DDGVNISDPTAFYDSNIA-NITLVVMTREERPYVMVKED-KNL 446
            :.:|:.::|....:|.|||:. :..|..||.....||:.: |.|:||.|..|.||||.|:: :.|
  Rat   375 YTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQL 439

  Fly   447 TGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMT 511
            .||.|:||:|:||...||..|..:||:.:|.|..||...|||..|||:|.||:..|||:|||.:|
  Rat   440 EGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLT 504

  Fly   512 INYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMAR 576
            |...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|
  Rat   505 ITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 569

  Fly   577 FSPYEW------KNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFF 635
            ||||||      :.|.......| ..|:|.|.||.||..|.|::||..::|::.|.|||||.|:|
  Rat   570 FSPYEWHLEDNNEEPRDPQSPPD-PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 633

  Fly   636 FCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWR 700
            |.||||||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.
  Rat   634 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWS 698

  Fly   701 YMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATP 762
            ||::.:.:||.||..||:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:|||
  Rat   699 YMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 763

  Fly   763 KGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLC 827
            |||...:.::||:|:|.|:|::..|.:|||.:.|: |.......:.|.:||.:.|:.|||.:|:.
  Rat   764 KGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILVG 827

  Fly   828 GLALAVVVAIFEFCWNSR---KNL----NTEN 852
            ||.||::||:.|||:.||   |.:    ||:|
  Rat   828 GLGLAMMVALIEFCYKSRAESKRMKLTKNTQN 859

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.