Protein Alignment CG11155 and Gria3

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 877
• Identity: 331/877 - (37%)
• Similarity: 492/877 - (56%)
• Gaps: 59/877 - (6%)

  Fly    16 GRSYLKKICCSYIILSILVISN-ALPPVIRVGAIFTEDERESSIESAFKYAI--YRINKEKTLLP 77
            |:|.|:.:  .:::|.:|..|: ..|..|.:|.:|..:..:.  .|||::|:  |..|:..|..|
  Rat     2 GQSVLRAV--FFLVLGLLGHSHGGFPNTISIGGLFMRNTVQE--HSAFRFAVQLYNTNQNTTEKP 62

  Fly    78 NTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEA----YDIPHIEGR 138
             ..|.|.::::...:||..|...|||...||.||||..|.:..:.:.|.|.|    :..|.....
  Rat    63 -FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTD 126

  Fly   139 IDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---LFNLMHSSTETKAEMY 200
            .|:     :|.|.:.|:   |..|...::.|..|.|...:|:.:.|   |..:|.::.:...::.
  Rat   127 ADV-----QFVIQMRPA---LKGAILSLLGYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVT 183

  Fly   201 IRQA----SPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLET 261
            .|..    ....:|:::..:.:::..:.::|.....|.:....::.|..:...||||........
  Rat   184 ARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTD 248

  Fly   262 YDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFA 326
            ..||...:...|||.|::|:.::....:.|.:..:|..........:| ::..|||..|::...|
  Rat   249 ILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAP-LKYTSALTHDAILVIA 312

  Fly   327 NGLHFLNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNI 384
            ....:|   ..|...:.......|      ..|:.||.:...:......|:||.:|| ..|||..
  Rat   313 EAFRYL---RRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTN 374

  Fly   385 FKLDILKLKQEKIQKVGYWHP-DDGVNISDPTAFYDSNIA-NITLVVMTREERPYVMVKED-KNL 446
            :.:|:.::|....:|.|||:. :..|..||.....||:.: |.|:||.|..|.||||.|:: :.|
  Rat   375 YTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQL 439

  Fly   447 TGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMT 511
            .||.|:||:|:||...||..|..:||:.:|.|..||...|||..|||:|.||:..|||:|||.:|
  Rat   440 EGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLT 504

  Fly   512 INYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMAR 576
            |...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|
  Rat   505 ITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 569

  Fly   577 FSPYEW------KNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFF 635
            ||||||      :.|.......| ..|:|.|.||.||..|.|::||..::|::.|.|||||.|:|
  Rat   570 FSPYEWHLEDNNEEPRDPQSPPD-PPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 633

  Fly   636 FCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWR 700
            |.||||||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.
  Rat   634 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWS 698

  Fly   701 YMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATP 762
            ||::.:.:||.||..||:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:|||
  Rat   699 YMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 763

  Fly   763 KGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLC 827
            |||.....::||:|:|.|:||:..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|:.
  Rat   764 KGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGE-CGAKDSGSKDKTSALSLSNVAGVFYILVG 827

  Fly   828 GLALAVVVAIFEFCWNSR---KNL----NTEN 852
            ||.||::||:.|||:.||   |.:    ||:|
  Rat   828 GLGLAMMVALIEFCYKSRAESKRMKLTKNTQN 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	87/389 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	205/378 (54%)
		Lig_chan	554..828	CDD:459656	149/282 (53%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	87/388 (22%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	207/384 (54%)