Protein Alignment CG11155 and GRIN1

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001424259.1
• Gene: GRIN1 / 2902
• HGNCID: 4584
• Length: 959
• Species: Homo sapiens
• Alignment Length: 920
• Identity: 232/920 - (25%)
• Similarity: 392/920 - (42%)
• Gaps: 176/920 - (19%)

  Fly    40 PPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQL 104
            |.::.:||:.:..:.|.....|...|..|....|..|..|.:.:      :.::.:....||..|
Human    24 PKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTH------KPNAIQMALSVCEDL 82

  Fly   105 -EAGVQAIF-----GPTDALLASHVQSICEAYDIP--HIEGRIDLEYNSKEFSINL---YPSHTL 158
             .:.|.||.     .|.|....:.|......|.||  .:..|:.: |:.|...::.   .|.::.
Human    83 ISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSI-YSDKSIHLSFLRTVPPYSH 146

  Fly   159 LTLAYRDIMVYLNWTKVAIIYEEDY-------GLFNLMHS-STETKAEMY--IRQASPDSYR--- 210
            .:..:.::|...:|..:.::..:|:       .|..|:.. .:::|...|  :.|.|.|:.|
Human   147 QSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPK 211

  Fly   211 ---------------QVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLE 260
                           .:|...::.|...||:..:.....:.:|:...|.|....|.::....::.
Human   212 AEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREIS 276

  Fly   261 TYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAF 325
            ...|   ||....|.                         ||..|||    :.|||.:.|:|...
Human   277 GNAL---RYAPDGIL-------------------------GLQLING----KNESAHISDAVGVV 309

  Fly   326 ANGLHFLNLDNHQNFYIKNLSCTSD-QTWNDGISLYNQI--NAAITDGLTGTVQFVE-GRRNIFK 386
            |..:|  .|...:|.......|..: ..|..| .|:.::  ::...||:||.|:|.| |.|....
Human   310 AQAVH--ELLEKENITDPPRGCVGNTNIWKTG-PLFKRVLMSSKYADGVTGRVEFNEDGDRKFAN 371

  Fly   387 LDILKLKQEKIQKVGYWH-----PDD------GVNISDPTAFYDSNIANITLVVMTREERPYVMV 440
            ..|:.|:..|:.:||.::     |:|      |.....|..:..|.    .|.::|..:.|:|.|
Human   372 YSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMST----RLKIVTIHQEPFVYV 432

  Fly   441 ---------KEDKNLTGNLRFE-----------------------GFCIDLLKAIATQVGFQYKI 473
                     ||:..:.|:...:                       |||||||..:|..:.|.|::
Human   433 KPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEV 497

  Fly   474 ELVPDNMYGVYIPETNS----WNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGIL 534
            .||.|..:|......||    |||::.||:..:||:.||.:|||..|...|:|:|||...|:.||
Human   498 HLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTIL 562

  Fly   535 FK--VPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPY-EWKNPHPCYKETDIVE 596
            .|  :|.|   .|.|||.|....:||.|..:..:|:..|:::.||||: .:|     ....:..|
Human   563 VKKEIPRS---TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFK-----VNSEEEEE 619

  Fly   597 NQFSISNSFWFITGTFLRQGSGLN-PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISP 660
            :..::|::.||..|..|..|.|.. |::.|.||:|..|..|.:||::||||||||||.::|....
Human   620 DALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEER 684

  Fly   661 IESASD--LAEQTE-ISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYE---DGIK 719
            |...:|  |...:: ..|.|::..|...:|| .::.: ..|:|:||..       .||   :.|:
Human   685 ITGINDPRLRNPSDKFIYATVKQSSVDIYFR-RQVEL-STMYRHMEKH-------NYESAAEAIQ 740

  Fly   720 RVMEGS-YAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGI 783
            .|.:.. :||:.:|.:|::...:.|:|...|.|....|:||...|.|||:..:||:||:..|.|.
Human   741 AVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGF 805

  Fly   784 IQILYDKWWKNTGDVCNRDDKSKESKANA---LGVENIGGVFVVLLCGLALAVVVAIFEFCWNSR 845
            ::.| ||.|....: |       :|::||   |..||:.|||:::..|:...:.:...|..:...
Human   806 MEDL-DKTWVRYQE-C-------DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH 861

  Fly   846 KNLNTENQSL 855
            |:...:...|
Human   862 KDARRKQMQL 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	83/422 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	131/415 (32%)
		Lig_chan	554..828	CDD:459656	89/285 (31%)
GRIN1	NP_001424259.1	None