Protein Alignment CG11155 and GRIK5

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 352/859 - (40%)
• Similarity: 508/859 - (59%)
• Gaps: 61/859 - (7%)

  Fly    29 ILSILVISNALPPV-----IRVGAIFTED------ERESSIESAFKYAIYRINKEKTLLPNTQLV 82
            :|.:|:::.|.|..     :|:.||..:.      ||     .|...|..:||....:....::.
Human     5 LLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGER-----LALALAREQINGIIEVPAKARVE 64

  Fly    83 YDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDA-LLASHVQSICEAYDIPHI----EGRIDLE 142
            .||..:.||..:.||..:|..|..||.::.||:.: ..||.|..||...:||||    |....|:
Human    65 VDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQ 129

  Fly   143 YNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMH------SSTETKAEMYI 201
            | .:..|::||||:..::||...|:...|:...::|..:...|..|..      .|.||.:...:
Human   130 Y-LRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRML 193

  Fly   202 ---RQASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYD 263
               |..:|     :|:.||..::..||:|.|.|......|...:|.|....|.|:.||.|.....
Human   194 DDSRDPTP-----LLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILH 253

  Fly   264 LEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI--QTESALMFDSVYAFA 326
            |:....:|.||..|.:.:.....|.|.:   :.|..:..:....|.|:  ...:|||||:|:...
Human   254 LDGIVEDSSNILGFSMFNTSHPFYPEFV---RSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315

  Fly   327 NGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDIL 390
            :.:..||  ..|...:|.|:|||...|..|.||.|.:.....|||||.|:| .:|:|..:.|.||
Human   316 SAVRELN--RSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRIL 378

  Fly   391 KLKQEKIQKVGYWHPDDGVNISDPTAFYDSN----IANITLVVMTREERPYVMVKED-KNLTGNL 450
            :..::..:::|.|:.:..:.::..|  .|.|    :||.||||.|..|.||||.:.: :.|:||.
Human   379 EKSRQGHREIGVWYSNRTLAMNATT--LDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNE 441

  Fly   451 RFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETN-SWNGIVQELMER-RADLAVASMTIN 513
            ||||||:|:|:.:|..:.|:|::.||.|.:||.  ||.| ||.|:|.||:.| :||||||:.||.
Human   442 RFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA--PEPNGSWTGMVGELINRQKADLAVAAFTIT 504

  Fly   514 YARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFS 578
            ..||.||||:||||.|||.||::|...:....|||::|.:..:||::|.||:.||..||:.||.|
Human   505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLS 569

  Fly   579 PYEWKNPHPCYK-ETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIIS 642
            ||||.|||||.: ...|:|||:::.||.||..|.|::|||.:.|:|.|||.|.|.|:.|.|||||
Human   570 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIIS 634

  Fly   643 SYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKT 707
            ||||||||||||:||..|:|||.|||:||.|.|||:..|||||||::|:...||:||.||::::.
Human   635 SYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQP 699

  Fly   708 AVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKIS 772
            :||||:.|:||.||:...||||:||||.:|..:.:|||||||||||:|||||..|.|||:||:|:
Human   700 SVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEIT 764

  Fly   773 LAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAI 837
            ||||:|||...::||..|||:.     .|..|.::.:|..||:|||||:|:||:|||.:||.||:
Human   765 LAILQLQENNRLEILKRKWWEG-----GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAV 824

  Fly   838 FEFCWNSRKNLNTE 851
            .||.|::|::..:|
Human   825 MEFIWSTRRSAESE 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	109/391 (28%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	209/372 (56%)
		Lig_chan	554..828	CDD:459656	155/274 (57%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	109/393 (28%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	209/372 (56%)