Protein Alignment CG11155 and GRIK4

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 895
• Identity: 358/895 - (40%)
• Similarity: 525/895 - (58%)
• Gaps: 60/895 - (6%)

  Fly    18 SYLKKICCSYIILSILVISNALPPVIRVGAIFTEDERESS--IESAFKYAIYRINKEKTLLPNTQ 80
            ::|..:.||             |..:|:.||. :|..|.|  ...:...|..|||:....|...:
Human    13 AWLVMVACS-------------PHSLRIAAIL-DDPMECSRGERLSITLAKNRINRAPERLGKAK 63

  Fly    81 LVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASH-VQSICEAYDIPHIEGRID--LE 142
            :..||..:.||..:.|.:.:|..|..||.|:.||:.:..:|. :.:||...::||.:...:  ::
Human    64 VEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVK 128

  Fly   143 YNSKEF-SINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFN---LMHSSTETKAEMYIRQ 203
            :..:.| ::||:||:|.:::|...|:.:.|.|...:|..:...|.|   |:.....:|..:.:|.
Human   129 FQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRM 193

  Fly   204 ASPDSYRQ---VLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLE 265
            .  |..|.   :|:.||..:...||:..|.|...:......:|.|....|.|:||..:.....::
Human   194 L--DDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMD 256

  Fly   266 DFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI--QTESALMFDSVYAFANG 328
            ....:.|||..|.:.:.....:.|....:.:......|.:   |:.  ...|||:||:|||....
Human   257 SLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHV---PFTGPALSSALLFDAVYAVVTA 318

  Fly   329 LHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDILKL 392
            :..||  ..|...:|.|||.|.|.|..|.||.|.:.....:||||.::| .:|:|:.:.|.||:.
Human   319 VQELN--RSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQF 381

  Fly   393 KQEKIQKVGYWHPDDGVNISDPTAFYDSNIA----NITLVVMTREERPYVMVK-EDKNLTGNLRF 452
            .:...:::|.||..:|:::.  :..|.|||:    |.||||.|..|.||:|:| ..:.:.||.|:
Human   382 TRNGFRQIGQWHVAEGLSMD--SHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRY 444

  Fly   453 EGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETN-SWNGIVQELMERRADLAVASMTINYAR 516
            ||||:|:||.:|..:.|.|||.||.|.:|||  ||.| :|.|:|.||:.|:||||||.:||...|
Human   445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGV--PEANGTWTGMVGELIARKADLAVAGLTITAER 507

  Fly   517 ESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYE 581
            |.||||:||||.|||.||::|...:....|||::|.:..:||::|.||:.||..||::||.:|||
Human   508 EKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 572

  Fly   582 WKNPHPCYK-ETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYT 645
            |.:||||.: ..:::.||:|:.||.||..|.|::|||.:.|:|.|||.|.|.|:.|.||||||||
Human   573 WYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYT 637

  Fly   646 ANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVF 710
            |||||||||:||..||||..|||:||.|.|||:.|||:||||::|:...||:||.||.:::.:||
Human   638 ANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVF 702

  Fly   711 VKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAI 775
            ||:.|:||.||:..:||||:||||.:|..||:|||||||||||:|||||..|.||.:||:..|||
Human   703 VKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAI 767

  Fly   776 LELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEF 840
            |:|||...::||..|||:  |..|   .|.::.:|..||:|||||:||||:|||.:|:.:|:.||
Human   768 LQLQENNRLEILKRKWWE--GGKC---PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827

  Fly   841 CWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVP 890
            .|..|.:..|| .|:|.||..|||..:.|..|   ..||:|.    ::||
Human   828 LWTLRHSEATE-VSVCQEMVTELRSIILCQDS---IHPRRRR----AAVP 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	102/383 (27%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	207/371 (56%)
		Lig_chan	554..828	CDD:459656	154/274 (56%)
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	102/387 (26%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	207/371 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956