Protein Alignment CG11155 and GRIK3

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 910
• Identity: 394/910 - (43%)
• Similarity: 573/910 - (62%)
• Gaps: 62/910 - (6%)

  Fly    23 ICCSYIILSILVISNALPPVIRVGAIFT-EDERESSI----ESAFKYAIYRINKEKTLLPNTQLV 82
            :.|::.|..    |..:|.|||:|.||. .|...:.:    |.||:::...||:.:||||||.|.
Human    20 LVCAFWIPD----SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLT 80

  Fly    83 YDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR-----IDLE 142
            |||:.:...|||..|||.|.||..||.|||||:.....:.|||||.|.::|||:.|     :|
Human    81 YDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLD-- 143

  Fly   143 YNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMH---SSTETKAEMYIRQA 204
             |...|.:||||.:..|:.|..|::.||.|....::|::..||..|..   :.:.....:.|||.
Human   144 -NKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQL 207

  Fly   205 SPDS--YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDF 267
            ..||  .|.:|:.:::...::||.|.:.:......:..:.:.|....||::|||.||...|||.:
Human   208 PIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPY 272

  Fly   268 RYNSVNITAFRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAF 325
            ||:.||:|.||:::||:.....::.:  |::||     .:||  ::|  .:.|::||::|:|
Human   273 RYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGL--LDG--VMMTDAALLYDAV--- 330

  Fly   326 ANGLHFLNL--DNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFK 386
                |.:::  .......:.:|.|...:.|..|....|.|..|..:||||.:.|  ..|.|..|.
Human   331 ----HIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFD 391

  Fly   387 LDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNI----ANITLVVMTREERPYVMV-KEDKNL 446
            |||:.||::.::|||.|.|.||:||::.......|:    .|.:|:|.|..|.|:||. |.|:.|
Human   392 LDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTL 456

  Fly   447 TGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMT 511
            .||.||||:||||||.:|..:||.|:|.||.|..||.. .:...|||:|:||::.:||||||.:|
Human   457 YGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQ-DDKGQWNGMVKELIDHKADLAVAPLT 520

  Fly   512 INYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMAR 576
            |.:.||..|||:||||.||:.||::.|......:|||:|||:.:||:|||.||:.||..|||:||
Human   521 ITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIAR 585

  Fly   577 FSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIII 641
            ||||||.:.|||...:::|||.|::.|||||..|:.::|||.|.|||.||||:||.|:||.||||
Human   586 FSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIII 650

  Fly   642 SSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRK 706
            ||||||||||||||||.|||:||.|||:||:|.||.::.|:|||||:.|||..::|||.:|.::.
Human   651 SSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKP 715

  Fly   707 TAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKI 771
            :|: ||..|:||:|.:...||.|||||.::|..||:|||||||||:|||||||.||.|||:||||
Human   716 SAL-VKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKI 779

  Fly   772 SLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVA 836
            ::|||:|||:..:.|:.:|||:.:|  | .::::||  |:|||::.|||:|:||..||.|:|:||
Human   780 TIAILQLQEEDKLHIMKEKWWRGSG--C-PEEENKE--ASALGIQKIGGIFIVLAAGLVLSVLVA 839

  Fly   837 IFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVPTYVPSNVSTSN 901
            :.||.:..||....|.:|.||.:|:|:||::.|. .:.:|:|:....:...:|     .|:.|.|
Human   840 VGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQ-RRVKHKPQPPMMVKTDAV-----INMHTFN 898

  Fly   902  901
            Human   899  898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	134/394 (34%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	213/369 (58%)
		Lig_chan	554..828	CDD:459656	161/273 (59%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	133/393 (34%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	213/369 (58%)