DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11155 and GRIK2

DIOPT Version :9

Sequence 1:NP_651941.2 Gene:CG11155 / 43822 FlyBaseID:FBgn0039927 Length:910 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:878 Identity:394/878 - (44%)
Similarity:570/878 - (64%) Gaps:42/878 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 IILSILVI--SNALPPVIRVGAIF--TEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYV 88
            ::|.:|.|  |.....|:|.|.||  .|.....:.|.||::|:..||:.:||||||.|.||.:.:
Human    19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKI 83

  Fly    89 PRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR--IDLEYNSKEFSIN 151
            ...|||..:||.|.||..||.|||||:.:..|:.|||||.|..:|||:.|  ..:..|...|.::
Human    84 NLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVS 148

  Fly   152 LYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLF---NLMHSSTETKAEMYIRQASPDS--YRQ 211
            |||..:.|:.|..|::.:..|..|.::|::..||.   .|:.:.:.....:.|||...|:  .:.
Human   149 LYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKP 213

  Fly   212 VLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITA 276
            :|:.:::.:.:.:|.|.:........:..|.:.|....|||:|||.||...|:|.:||:.||:|.
Human   214 LLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278

  Fly   277 FRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNL 334
            ||:::.::.:...:|.:  |::||     .:||  ::|  ::.|::|||:|:|:..:     :.:
Human   279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGL--LDG--FMTTDAALMYDAVHVVS-----VAV 334

  Fly   335 DNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFKLDILKLKQEKI 397
            .......:.:|.|...:.|..|....:.|..|..:||||.:.|  ..|.|..|.||::.||:|.:
Human   335 QQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGL 399

  Fly   398 QKVGYWHPDDGVNISD-----PTAFYDSNIANITLVVMTREERPYVMVKE-DKNLTGNLRFEGFC 456
            :|:|.|.|..|:|:::     |....|| ::|.:|:|.|..|.|||:.|: ||.|.||.||||:|
Human   400 EKIGTWDPASGLNMTESQKGKPANITDS-LSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYC 463

  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVID 521
            ||||:.::|.:||.|:|.||.|..||........|||:|:||::.:||||||.:.|.|.||.|||
Human   464 IDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVID 528

  Fly   522 FTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPH 586
            |:||||.|||.||::.|......:|||:|||:.:||:|:|.||:.||..|||:||||||||.|||
Human   529 FSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH 593

  Fly   587 PCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAF 651
            ||..::|:|||.|::.|||||..|..::|||.|.|||.|||||||.|:||.||||||||||||||
Human   594 PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658

  Fly   652 LTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYED 716
            ||||||.|||:||.|||:||:|.||.:|.|:|||||:.|||..|.|||.:|.:|:.:|.||:.|:
Human   659 LTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEE 723

  Fly   717 GIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEK 781
            ||:||:...||||||||.:::..||:|||||||||:||||||:.||.|||:||||::|||:|||:
Human   724 GIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEE 788

  Fly   782 GIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRK 846
            |.:.::.:|||:..|  | .:::|||  |:||||:||||:|:||..||.|:|.||:.||.:.|:|
Human   789 GKLHMMKEKWWRGNG--C-PEEESKE--ASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKK 848

  Fly   847 NLNTENQSLCSEMAEELRFAMHCHGSKSRHRPR 879
            |...|.:|.||.|.||||.::.|. .:.:|:|:
Human   849 NAQLEKRSFCSAMVEELRMSLKCQ-RRLKHKPQ 880

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG11155NP_651941.2 PBP1_iGluR_Kainate 44..410 CDD:107377 123/383 (32%)
ANF_receptor 61..393 CDD:279440 109/347 (31%)
PBP2_iGluR_Kainate 424..793 CDD:270432 221/369 (60%)
Lig_chan 555..829 CDD:278489 170/273 (62%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 124/385 (32%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 221/369 (60%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)