DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GRID1

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	901	Identity:	262/901 - (29%)
Similarity:	447/901 - (49%)	Gaps:	114/901 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEA 106
            :|.:||||  :|..:..:..|:.|:..::....:|.:.::.|.|:.:..::.|:..::.|..:..
Human    23 IIHIGAIF--EENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQ 85

  Fly   107 GVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYN---SKEFSINLYPS--HTLLTLAYR-- 164
            |:.|:...|....|:.:||:.:|..|||    :.::.|   |...:.:|.||  ....|||.|
Human    86 GILALVTSTGCASANALQSLTDAMHIPH----LFVQRNPGGSPRTACHLNPSPDGEAYTLASRPP 146

  Fly   165 ----DIMV----YLNWTKVAIIYEEDY---GLFNLMHSSTETKAEMYIRQASP------------ 206
                |:|:    .|.|.|..:.|:.:|   ||.:.:..::....::.:::...
Human   147 VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTT 211

  Fly   207 ------DSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLE 265
                  :.||..||        :.|:..:|....||....::..:.....|::|...::...::.
Human   212 MKTEELNRYRDTLR--------RAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEIL 268

  Fly   266 DFRYNSV-NITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSP------YIQTESALMFDSVY 323
            |..:::: .:|..|.:...:|.     ||.....::.:.::...|      .:|..:..::|||.
Human   269 DLVHSALGRMTVVRQIFPSAKD-----NQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVL 328

  Fly   324 AFANGLHFLNLDNHQNFYIKNLSC--TSDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIF- 385
            ..||..| ..|::.:...:.:|:|  .|.:.||.|.|:.:.|......||||.::|.|...|.:
Human   329 MLANAFH-RKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYV 392

  Fly   386 KLDILKLKQEK-----IQKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKN 445
            :.:||.....:     ::|:..|..:.|:|.|.......|.:..:||.|:|..|.|:|||.|  |
Human   393 QFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAE--N 455

  Fly   446 LTGN-LRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVAS 509
            :.|. .|::||.||:|.|:|..:||:|:|...||..||..:..| ||||::.||:.:|||||:::
Human   456 ILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKRADLAISA 519

  Fly   510 MTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVM 574
            :||...||||:||:|.:|:..:|||.|.| .:...:||...|....:|..:.||..:|...:||:
Human   520 ITITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVL 583

  Fly   575 ARFSPYEWKN---PHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFF 636
            .|......::   |.|....|        :.::.|.:.|.|::||...:..:.:.|||.|.|:.|
Human   584 NRIQAVRAQSAAQPRPSASAT--------LHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLF 640

  Fly   637 CLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFR---------DSKI 692
            .||:.|||||||||||||.||.:||.:..||::|.|:||||:...:...:||         ||
Human   641 TLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDS-- 703

  Fly   693 GIYQKMWRYM-ENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYA--VQRDCNLTQIGGLLDS 754
             .:.::||.: :|......|.:..:||::..:|:||||.:..:::||  ...||::|.||..:.|
Human   704 -TFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISS 767

  Fly   755 KGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIG 819
            ||||||...|||:||..|..|||||:.|.:.:|..|||.:.|........|.::...:|.:.:..
Human   768 KGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFA 832

  Fly   820 GVFVVLLCGLALAVVVAIFEFCWNSRK------------NLNTENQSLCSEMAEEL 863
            |||.:|..||.||.:||..|..|||.:            ||...::.:.|.|.|::
Human   833 GVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDI 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	85/416 (20%)
		ANF_receptor	61..393	CDD:279440	77/377 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	150/384 (39%)
		Lig_chan	555..829	CDD:278489	100/288 (35%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		89/432 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	85/417 (20%)
		ANF_receptor	41..400	CDD:279440	77/376 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	150/384 (39%)
		Lig_chan	564..841	CDD:278489	100/287 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6092
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790