Protein Alignment CG11155 and GRIA4

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 843
• Identity: 334/843 - (39%)
• Similarity: 482/843 - (57%)
• Gaps: 58/843 - (6%)

  Fly    38 ALPPVIRVGAIF---TEDERESSIESAFKYAIYRINKEKTLLPNT-----QLVYDIEYVPRDDSF 94
            |.|..:::|.:|   |:.|     .:||:.||:..|..    ||.     .||..::.:...:||
Human    22 AFPSSVQIGGLFIRNTDQE-----YTAFRLAIFLHNTS----PNASEAPFNLVPHVDNIETANSF 77

  Fly    95 RTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYPSHTLL 159
            ..|...|||...||.||||..|......:.|.|.|..|..|......|..| :|.:.|.||   |
Human    78 AVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGES-QFVLQLRPS---L 138

  Fly   160 TLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAE-------MYIRQASPDSYRQVLRAIR 217
            ..|...::.:..|.....:|:.|.| ::::.:..|...:       :.:...:..||||:|..:.
Human   139 RGALLSLLDHYEWNCFVFLYDTDRG-YSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELD 202

  Fly   218 QKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDV 282
            :::..|.::|.....:::....|:.:..:...|||:......:...||.|.:...|:|.|:|||.
Human   203 RRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDF 267

  Fly   283 DSKRYLEVINQMQKL---QHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFYIKN 344
            ::...::::::.:||   ::.|.:|    |...| |||.:|.|...|.....|   ..|...|..
Human   268 NTPMVIKLMDRWKKLDQREYPGSET----PPKYT-SALTYDGVLVMAETFRSL---RRQKIDISR 324

  Fly   345 LSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQEKIQKVGY 402
            .....|      ..|..||.:...:......||||.|||.. |||..:.:|:.:||....:||||
Human   325 RGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGY 389

  Fly   403 WHP-DDGVNISD-PTAFYD-SNIANITLVVMTREERPYVMVKEDKNL-TGNLRFEGFCIDLLKAI 463
            |:. |..|.|.| ||...| :.|.|.|:||.|..|.||||.|::..: .||.::||:|:||...|
Human   390 WNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEI 454

  Fly   464 ATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMN 528
            |..:|.:|||.:|||..||....:|..|||:|.||:..:|::|:|.:||...||.||||:||||:
Human   455 AKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMS 519

  Fly   529 LGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHP-CYKE- 591
            |||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||....| ..||
Human   520 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEG 584

  Fly   592 -TDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVE 655
             :|...|:|.|.||.||..|.|::||..::|::.|.|||||.|:||.||||||||||||||||||
Human   585 PSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE 649

  Fly   656 RMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKR 720
            ||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.||.:.:.:||.:|..:|:.|
Human   650 RMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVAR 714

  Fly   721 V--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKG 782
            |  .:|.:|||:||||.:|..|| .|:..::||.|||||||:||||||..|..::||:|:|.|.|
Human   715 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAG 779

  Fly   783 IIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSR 845
            ::..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|:.||.||::||:.|||:.||
Human   780 VLDKLKNKWWYDKGE-CGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	104/394 (26%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	200/375 (53%)
		Lig_chan	554..828	CDD:459656	149/279 (53%)
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	103/393 (26%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	202/381 (53%)