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Protein Alignment CG11155 and GRIA3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	892	Identity:	332/892 - (37%)
Similarity:	497/892 - (55%)	Gaps:	67/892 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRKKREIVIKENIQGRSYLKKICCSYIILSILVISN-ALPPVIRVGAIFTEDERESSIESAFKY 64
            |.|:|:        .|:|.|:.:  .:::|.:|..|: ..|..|.:|.:|..:..:.  .|||::
Human     1 MARQKK--------MGQSVLRAV--FFLVLGLLGHSHGGFPNTISIGGLFMRNTVQE--HSAFRF 53

  Fly    65 AI--YRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSIC 127
            |:  |..|:..|..| ..|.|.::::...:||..|...|||...||.||||..|.:..:.:.|.|
Human    54 AVQLYNTNQNTTEKP-FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFC 117

  Fly   128 EA----YDIPHIEGRIDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---L 185
            .|    :..|......|:     :|.|.:.|:   |..|...::.:..|.|...:|:.:.|   |
Human   118 GALHTSFVTPSFPTDADV-----QFVIQMRPA---LKGAILSLLGHYKWEKFVYLYDTERGFSIL 174

  Fly   186 FNLMHSSTETKAEMYIRQA----SPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMN 246
            ..:|.::.:...::..|..    ....:|:::..:.:::..:.::|.....|.:....::.|..:
Human   175 QAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKH 239

  Fly   247 DHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI 311
            ...||||..........||...:...|||.|::|:.::....:.|.:..:|..........:| :
Human   240 SRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAP-L 303

  Fly   312 QTESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDG 370
            :..|||..|::...|....:|   ..|...:.......|      ..|:.||.:...:......|
Human   304 KYTSALTHDAILVIAEAFRYL---RRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQG 365

  Fly   371 LTGTVQF-VEGRRNIFKLDILKLKQEKIQKVGYWHP-DDGVNISDPTAFYDS-NIANITLVVMTR 432
            :||.:|| ..|||..:.:|:.::|....:|.|||:. :..|..||.....|| :..|.|:||.|.
Human   366 MTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTI 430

  Fly   433 EERPYVMVKED-KNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQ 496
            .|.||||.|:: :.|.||.|:||:|:||...||..|..:||:.:|.|..||...|||..|||:|.
Human   431 LESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVG 495

  Fly   497 ELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVL 561
            ||:..|||:|||.:||...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::
Human   496 ELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIV 560

  Fly   562 AAYILVSFALFVMARFSPYEW------KNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLN 620
            .|||.||..||:::|||||||      :.|.......| ..|:|.|.||.||..|.|::||..::
Human   561 FAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPD-PPNEFGIFNSLWFSLGAFMQQGCDIS 624

  Fly   621 PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMT 685
            |::.|.|||||.|:||.||||||||||||||||||||:||||||.|||:||||:||||:.|||..
Human   625 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKE 689

  Fly   686 FFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQ 747
            |||.|||.:|:|||.||::.:.:||.||..||:.||  .:|.:|||:||||.:|..|| .|:..:
Human   690 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMK 754

  Fly   748 IGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANA 812
            :||.|||||||:||||||..|:.::||:|:|.|:|::..|.:|||.:.|: |.......:.|.:|
Human   755 VGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSA 818

  Fly   813 LGVENIGGVFVVLLCGLALAVVVAIFEFCWNSR---KNL----NTEN 852
            |.:.|:.|||.:|:.||.||::||:.|||:.||   |.:    ||:|
Human   819 LSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQN 865

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.