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Protein Alignment CG11155 and GRIA2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	868	Identity:	325/868 - (37%)
Similarity:	482/868 - (55%)	Gaps:	58/868 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ILVISNALPPVIRVGAIFTEDERESSIESAF------KYAIYRINKEKTLLPNTQLVYDIEYVPR 90
            |:.||..|.||: .|.||........|...|      :|:.:|:...:......:|...|:.:..
Human     4 IMHISVLLSPVL-WGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEV 67

  Fly    91 DDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYPS 155
            .:||..|...|||...||.||||..|....:.:.|.|....:..|......: .:..|.|.:.|.
Human    68 ANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTD-GTHPFVIQMRPD 131

  Fly   156 HTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNL---MHSSTETKAEMYI-------RQASPDSYR 210
               |..|...::.|..|.|.|.:|:.|.||..|   :.|:.|.|.::..       .....:.||
Human   132 ---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYR 193

  Fly   211 QVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNIT 275
            .:.:.:..|:..::|:|.....:......::.:..:...|||:.........||...::...|::
Human   194 SLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVS 258

  Fly   276 AFRLVDVDS---KRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNH 337
            .|::||.|.   .:::|..:.:::.::.|..|..    |:..|||.:|:|......  |.|| ..
Human   259 GFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTT----IKYTSALTYDAVQVMTEA--FRNL-RK 316

  Fly   338 QNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQE 395
            |...|.......|      ..|..|:.:...:.....:||:|.::|.: |:|..:.::|::||..
Human   317 QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTN 381

  Fly   396 KIQKVGYWHPDDG--VNISD-PTAFYDSNIANITLVVMTREERPYVMVKED-KNLTGNLRFEGFC 456
            ..:|:|||...|.  |.::: |:....|.:.|.|:||.|..|.||||:|:: :.|.||.|:||:|
Human   382 GPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYC 446

  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVID 521
            :||...||...||:||:.:|.|..||....:|..|||:|.||:..:||:|:|.:||...||.|||
Human   447 VDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVID 511

  Fly   522 FTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPH 586
            |:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||....
Human   512 FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEE 576

  Fly   587 -PCYKETDIVE--NQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANL 648
             ...:||...|  |:|.|.||.||..|.|::||..::|::.|.|||||.|:||.|||||||||||
Human   577 FEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 641

  Fly   649 AAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKT 713
            |||||||||:||||||.||::||||:||||:.|||..|||.|||.::.|||.||.:.:.:|||:|
Human   642 AAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRT 706

  Fly   714 YEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAI 775
            ..:|:.||  .:|.||:|:||||.:|..|| .|:..::||.||||||||||||||..|..::||:
Human   707 TAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAV 771

  Fly   776 LELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEF 840
            |:|.|:|::..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|:.||.||::||:.||
Human   772 LKLSEQGVLDKLKNKWWYDKGE-CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835

  Fly   841 CWNSR---------KNLNTENQS 854
            |:.||         ||....|.|
Human   836 CYKSRAEAKRMKVAKNAQNINPS 858

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.