Protein Alignment CG11155 and GRIA1

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 866
• Identity: 338/866 - (39%)
• Similarity: 494/866 - (57%)
• Gaps: 66/866 - (7%)

  Fly    23 ICCSYIILSILVISNA-----------LPPV---IRVGAIFTEDERESSIESAFKYAIYRINKEK 73
            :|||..:...|.::..           |.||   ..|..:|  ..::|...:||::|:.::.:..
Human     1 MCCSTHLFQPLQLAGGLEWPWSNLLCFLTPVKLHPEVWGLF--PNQQSQEHAAFRFALSQLTEPP 63

  Fly    74 TLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR 138
            .|||      .|:.|...|||..|.:.|||...||.||||..:....:.:.|.|.|..:..|...
Human    64 KLLP------QIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPS 122

  Fly   139 IDLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAE----- 198
            ..:: .|.:|.:.|.|.   |..|...|:.:..|.|...||:.|.|| :::....:|.||
Human   123 FPVD-TSNQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDADRGL-SVLQKVLDTAAEKNWQV 182

  Fly   199 --MYIRQASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLET 261
              :.|...:.:.||.:.:.:.:|:...::||.....:.:....|::|:.|...|||:........
Human   183 TAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMD 247

  Fly   262 YDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQK---LQHNGLDTINGSPYIQTESALMFDSVY 323
            .||..|:.:..|:|.|:||:.......:::.|.:.   ..|..:|....    :..|||.:|.|.
Human   248 IDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRP----KYTSALTYDGVK 308

  Fly   324 AFANGLHFLNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GR 381
            ..|.....|   ..|...|.......|      ..|..||.:...:.....:||||.|||.| ||
Human   309 VMAEAFQSL---RRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR 370

  Fly   382 RNIFKLDILKLKQEKIQKVGYWHPDDGV--NISDPTAFYD-SNIANITLVVMTREERPYVMVKED 443
            |..:.|.::::|.:.|:|:|||:.||..  ..:|..|..| |::.|.|.:|.|..|.||||:|::
Human   371 RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKN 435

  Fly   444 KN-LTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAV 507
            .| ..||.|:||:|::|...||..||:.|::|:|.|..||...|:|.:|||:|.||:..|||:||
Human   436 ANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAV 500

  Fly   508 ASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALF 572
            |.:||...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||
Human   501 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 565

  Fly   573 VMARFSPYEWKNPHPCYKE-----TDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGC 632
            :::|||||||.:..  ::|     |....|:|.|.||.||..|.|::||..::|::.|.|||||.
Human   566 LVSRFSPYEWHSEE--FEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 628

  Fly   633 WFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQK 697
            |:||.||||||||||||||||||||:||||||.|||:||||:|||||.|||..|||.|||.:::|
Human   629 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK 693

  Fly   698 MWRYMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGI 759
            ||.||::.:.:|||:|.|:|:.||  .:|.||:|:||||.:|..|| .|:..::||.||||||||
Human   694 MWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 758

  Fly   760 ATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVV 824
            ||||||..|:.::||:|:|.|:|::..|.:|||.:.|: |.......:.|.:||.:.|:.|||.:
Human   759 ATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYI 822

  Fly   825 LLCGLALAVVVAIFEFCWNSR 845
            |:.||.||::||:.|||:.||
Human   823 LIGGLGLAMLVALIEFCYKSR 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	101/387 (26%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	204/377 (54%)
		Lig_chan	554..828	CDD:459656	149/281 (53%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	101/385 (26%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	206/383 (54%)