DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grin2c

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	145/523 - (27%)
Similarity:	244/523 - (46%)	Gaps:	88/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 ILKLKQEKI-QKVGYWHPDDGVNISDPTAF--YDSNIANIT----LVVMTREERPYVMVKEDKNL 446
            ::.|.:.:: :.||.|  |.||.......:  |.:::..:.    |.|.|.||||:|:|:.....
  Rat   373 VIALNRHRLWEMVGRW--DHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPG 435

  Fly   447 TG--------------------------NLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYI 485
            ||                          .|..:|||||:||.:|..|.|.|.:.||.:..:|..:
  Rat   436 TGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRV 500

  Fly   486 PETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVP--TSQPTRLFSF 548
              ...|||::.|:..:|||:|:.|:|||..|..:|||:.||:..||.::....  |..|:   :|
  Rat   501 --RGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPS---AF 560

  Fly   549 MNPLAIEIWLYVLAAYI-LVSFALFVMARFSPYEW-------KNP-HPCYKETDIVENQFSISNS 604
            :.|.:..:|:.:....: :|:..:|:...|||..:       |.| .|          .|:|..|
  Rat   561 LEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGP----------SFTIGKS 615

  Fly   605 FWFITGTFLRQGSGL-NPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLA 668
            .|.:..........: ||:.|:::|:...|.||.:|.::|||||||||:..|:.|..:...||..
  Rat   616 VWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKK 680

  Fly   669 EQ------TEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSY- 726
            .|      ....:||:..|||....|.:...::..|.::.:        ::.||.:..:..|..
  Rat   681 FQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQ--------RSVEDALTSLKMGKLD 737

  Fly   727 AFLMESTMLDYAVQRD--CNLTQIGG--LLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQIL 787
            ||:.::.:|:|...:|  |.|..||.  :..:.|||||..|.|.|:..|.||:|:|...|..|.|
  Rat   738 AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKL 802

  Fly   788 YDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFC--WNSRKNLNT 850
            ...|   ...:|  .::..|..::.|.::|:.|||.:||..:.||::|..:|..  |..|.::..
  Rat   803 ETVW---LSGIC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPN 862

  Fly   851 ENQ 853
            .:|
  Rat   863 SSQ 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	6/21 (29%)
		ANF_receptor	61..393	CDD:279440	0/3 (0%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	121/421 (29%)
		Lig_chan	555..829	CDD:278489	80/294 (27%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	7/25 (28%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	122/427 (29%)
		NMDAR2_C	850..>925	CDD:402274	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740