Protein Alignment CG11155 and Grin2b

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 954
• Identity: 231/954 - (24%)
• Similarity: 387/954 - (40%)
• Gaps: 245/954 - (25%)

  Fly    24 CCS---YIILSILVISNA------LPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNT 79
            |||   :::|::|.:|.:      .||.|.:..|......|.:|:.|.:...:.   ..:::|..
  Rat     7 CCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH---HLSVVPRV 68

  Fly    80 QLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYN 144
            :||...|..|:                              |.:..||:......|:|.:..:..
  Rat    69 ELVAMNETDPK------------------------------SIITRICDLMSDRKIQGVVFADDT 103

  Fly   145 SKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMYIR-QASPDS 208
            .:|....:....:..||.  .|:.....:.:.:..:::..:|.....|.|.:|.:.:. ....|.
  Rat   104 DQEAIAQILDFISAQTLT--PILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW 166

  Fly   209 YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVN 273
            |           |:.|:....|.: :.|...|.....|.      |..::||...|.|
  Rat   167 Y-----------IFSIVTTYFPGY-QDFVNKIRSTIENS------FVGWELEEVLLLD------- 206

  Fly   274 ITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI-----QTESALMFD---SVYAFANGLH 330
               ..|.|.|||    :.||::|||         ||.|     :.|:..:|:   ||.....|..
  Rat   207 ---MSLDDGDSK----IQNQLKKLQ---------SPIILLYCTKEEATYIFEVANSVGLTGYGYT 255

  Fly   331 FL-------NLDNHQNFYIKNLSCTSDQTWN--------DGISLYNQINAAITDGLTG------- 373
            ::       :.|...:.:...|...|...|:        |||::   |..|.:|.|:.
  Rat   256 WIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAI---ITTAASDMLSEHSFIPEP 317

  Fly   374 -----------------------TVQFVEGRRNIFKLD----------ILKLKQEKIQKVGYWHP 405
                                   .|.| |||...|..|          ||..|:.|.::||.| .
  Rat   318 KSSCYNTHEKRIYQSNMLNRYLINVTF-EGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKW-K 380

  Fly   406 DDGVNISDPTAFY-------------DSNIANITLVVMTREERPYVMVKEDKNLTGNLR------ 451
            |..:.:.    :|             |.:::.:||     ||.|:|:|:....|:|...
  Rat   381 DKSLQMK----YYVWPRMCPETEEQEDDHLSIVTL-----EEAPFVIVESVDPLSGTCMRNTVPC 436

  Fly   452 --------------------FEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQ 496
                                .:|||||:||.|:..|.|.|.:.||.:..:|..|  ..:|||::.
  Rat   437 QKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI--NGTWNGMIG 499

  Fly   497 ELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVP--TSQPTRLFSFMNPLAIEIWLY 559
            |::.:||.:||.|:|||..|..|:||:.||:..||.::....  |..|:   :|:.|.:.::|:.
  Rat   500 EVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVM 561

  Fly   560 VLAAYILVS-FALFVMARFSPYEWKNPHPCYKE-TDIVENQFSISNSFWFITGTFLRQGSGL-NP 621
            :....::|| .|:||...|||..:..   |..: .:.....|:|..:.|.:.|........: ||
  Rat   562 MFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNP 623

  Fly   622 KATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQ------TEISYGTLEG 680
            |.|:::|:...|.||.:|.::|||||||||:..|..:..:...||...|      ....:||:..
  Rat   624 KGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPN 688

  Fly   681 GSTMTFFRDSKIGIYQKMWRYME--NRKTAVFVKTYEDGIKRVMEGSY-AFLMESTMLDYAVQRD 742
            |||....|::    |.:|..||.  |::..      :|.:..:..|.. ||:.::.:|:|...||
  Rat   689 GSTERNIRNN----YAEMHAYMGKFNQRGV------DDALLSLKTGKLDAFIYDAAVLNYMAGRD 743

  Fly   743 --CNLTQIGG--LLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDD 803
              |.|..||.  :..|.|||||..|.|.|:.::.||||:|...|.::.|...|.  || :|:  :
  Rat   744 EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TG-ICH--N 803

  Fly   804 KSKESKANALGVENIGGVFVVLLCGLALAVVVAIFE--FCWNSR 845
            :..|..::.|.::|:.|||.:|...:||:::..|.|  |.|..|
  Rat   804 EKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFR 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	79/432 (18%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	124/412 (30%)
		Lig_chan	554..828	CDD:459656	86/289 (30%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	81/439 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	128/427 (30%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		2/18 (11%)
		NMDAR2_C	840..1482	CDD:463148	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482