DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11155 and Grin2b

DIOPT Version :9

Sequence 1:NP_651941.2 Gene:CG11155 / 43822 FlyBaseID:FBgn0039927 Length:910 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:954 Identity:231/954 - (24%)
Similarity:387/954 - (40%) Gaps:245/954 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 CCS---YIILSILVISNA------LPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNT 79
            |||   :::|::|.:|.:      .||.|.:..|......|.:|:.|.:...:.   ..:::|..
  Rat     7 CCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH---HLSVVPRV 68

  Fly    80 QLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYN 144
            :||...|..|:                              |.:..||:......|:|.:..:..
  Rat    69 ELVAMNETDPK------------------------------SIITRICDLMSDRKIQGVVFADDT 103

  Fly   145 SKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMYIR-QASPDS 208
            .:|....:....:..||.  .|:.....:.:.:..:::..:|.....|.|.:|.:.:. ....|.
  Rat   104 DQEAIAQILDFISAQTLT--PILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDW 166

  Fly   209 YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVN 273
            |           |:.|:....|.: :.|...|.....|.      |..::||...|.|       
  Rat   167 Y-----------IFSIVTTYFPGY-QDFVNKIRSTIENS------FVGWELEEVLLLD------- 206

  Fly   274 ITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI-----QTESALMFD---SVYAFANGLH 330
               ..|.|.|||    :.||::|||         ||.|     :.|:..:|:   ||.....|..
  Rat   207 ---MSLDDGDSK----IQNQLKKLQ---------SPIILLYCTKEEATYIFEVANSVGLTGYGYT 255

  Fly   331 FL-------NLDNHQNFYIKNLSCTSDQTWN--------DGISLYNQINAAITDGLTG------- 373
            ::       :.|...:.:...|...|...|:        |||::   |..|.:|.|:.       
  Rat   256 WIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAI---ITTAASDMLSEHSFIPEP 317

  Fly   374 -----------------------TVQFVEGRRNIFKLD----------ILKLKQEKIQKVGYWHP 405
                                   .|.| |||...|..|          ||..|:.|.::||.| .
  Rat   318 KSSCYNTHEKRIYQSNMLNRYLINVTF-EGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKW-K 380

  Fly   406 DDGVNISDPTAFY-------------DSNIANITLVVMTREERPYVMVKEDKNLTGNLR------ 451
            |..:.:.    :|             |.:::.:||     ||.|:|:|:....|:|...      
  Rat   381 DKSLQMK----YYVWPRMCPETEEQEDDHLSIVTL-----EEAPFVIVESVDPLSGTCMRNTVPC 436

  Fly   452 --------------------FEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQ 496
                                .:|||||:||.|:..|.|.|.:.||.:..:|..|  ..:|||::.
  Rat   437 QKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI--NGTWNGMIG 499

  Fly   497 ELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVP--TSQPTRLFSFMNPLAIEIWLY 559
            |::.:||.:||.|:|||..|..|:||:.||:..||.::....  |..|:   :|:.|.:.::|:.
  Rat   500 EVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVM 561

  Fly   560 VLAAYILVS-FALFVMARFSPYEWKNPHPCYKE-TDIVENQFSISNSFWFITGTFLRQGSGL-NP 621
            :....::|| .|:||...|||..:..   |..: .:.....|:|..:.|.:.|........: ||
  Rat   562 MFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNP 623

  Fly   622 KATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQ------TEISYGTLEG 680
            |.|:::|:...|.||.:|.::|||||||||:..|..:..:...||...|      ....:||:..
  Rat   624 KGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPN 688

  Fly   681 GSTMTFFRDSKIGIYQKMWRYME--NRKTAVFVKTYEDGIKRVMEGSY-AFLMESTMLDYAVQRD 742
            |||....|::    |.:|..||.  |::..      :|.:..:..|.. ||:.::.:|:|...||
  Rat   689 GSTERNIRNN----YAEMHAYMGKFNQRGV------DDALLSLKTGKLDAFIYDAAVLNYMAGRD 743

  Fly   743 --CNLTQIGG--LLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDD 803
              |.|..||.  :..|.|||||..|.|.|:.::.||||:|...|.::.|...|.  || :|:  :
  Rat   744 EGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TG-ICH--N 803

  Fly   804 KSKESKANALGVENIGGVFVVLLCGLALAVVVAIFE--FCWNSR 845
            :..|..::.|.::|:.|||.:|...:||:::..|.|  |.|..|
  Rat   804 EKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFR 847

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG11155NP_651941.2 PBP1_iGluR_Kainate 44..410 CDD:107377 79/429 (18%)
ANF_receptor 61..393 CDD:279440 70/395 (18%)
PBP2_iGluR_Kainate 424..793 CDD:270432 124/412 (30%)
Lig_chan 555..829 CDD:278489 86/289 (30%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 82/444 (18%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 128/427 (30%)
HisJ <459..>542 CDD:223904 35/84 (42%)
Lig_chan 557..829 CDD:278489 86/289 (30%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 2/18 (11%)