DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grik4

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	356/887 - (40%)
Similarity:	523/887 - (58%)	Gaps:	55/887 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SYLKKICCSYIILSILVISNALPPVIRVGAIFTEDERESS--IESAFKYAIYRINKEKTLLPNTQ 80
            ::|..:.||             |..:|:.||. :|..|.|  ...:...|..|||:....|...:
  Rat    13 AWLLMVACS-------------PHSLRIAAIL-DDPMECSRGERLSITLAKNRINRAPERLGKAK 63

  Fly    81 LVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASH-VQSICEAYDIPHIEGRID--LE 142
            :..||..:.||..:.|.:.:|..|..||.|:.||:.:..:|. :.:||...::||.:...:  :.
  Rat    64 VEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVR 128

  Fly   143 YNSKEF-SINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFN---LMHSSTETKAEMYIRQ 203
            :..:.| ::||:||:|.:::|...|:.:.|.|...:|..:...|.|   |:.....:|..:.:|.
  Rat   129 FQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRM 193

  Fly   204 ASPDSYRQ---VLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLE 265
            .  |..|.   :|:.||..:...||:..|.|...:......:|.|....|.|:||..:.....::
  Rat   194 L--DDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMD 256

  Fly   266 DFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYI--QTESALMFDSVYAFANG 328
            ....:.|||..|.:.:.....:.|.   .|.|..:..:..:..|:.  ...|||:||:|||....
  Rat   257 SLVDDRVNILGFSIFNQSHAFFQEF---SQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTA 318

  Fly   329 LHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDILKL 392
            :..||  ..|...:|.|||.|.|.|..|.||.|.:.....:||||.::| .:|:|:.:.|.||:.
  Rat   319 VQELN--RSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQF 381

  Fly   393 KQEKIQKVGYWHPDDGVNISDPTAFYDSNIA----NITLVVMTREERPYVMVK-EDKNLTGNLRF 452
            .:...:::|.||..:|:::.  :..|.|||:    |.||||.|..|.||:|:| ..:::.||.|:
  Rat   382 TRNGFRQIGQWHVAEGLSMD--SRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQDMEGNDRY 444

  Fly   453 EGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETN-SWNGIVQELMERRADLAVASMTINYAR 516
            ||||:|:||.:|..:.|.|||.||.|.:|||  ||.| :|.|:|.||:.|:||||||.:||...|
  Rat   445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGV--PEANGTWTGMVGELIARKADLAVAGLTITAER 507

  Fly   517 ESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYE 581
            |.||||:||||.|||.||::|...:....|||::|.:..:||::|.||:.||..||::||.:|||
  Rat   508 EKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 572

  Fly   582 WKNPHPCYK-ETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYT 645
            |.:||||.: ..:::.||:|:.||.||..|.|::|||.:.|:|.|||.|.|.|:.|.||||||||
  Rat   573 WYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYT 637

  Fly   646 ANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVF 710
            |||||||||:||..||||..|||:||.|.|||:.|||:||||::|:...||:||.||.:::.:||
  Rat   638 ANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVF 702

  Fly   711 VKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAI 775
            ||:.|:||.||:..:||||:||||.:|..||:|||||||||||:|||||..|.||.:||:..|||
  Rat   703 VKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAI 767

  Fly   776 LELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEF 840
            |:|||...::||..|||:  |..|   .|.::.:|..||:|||||:||||:|||.:|:.:|:.||
  Rat   768 LQLQENNRLEILKRKWWE--GGKC---PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827

  Fly   841 CWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRS 882
            .|..|.:..:| .|:|.||..|||..:.|  ..:.|..|:||
  Rat   828 LWTLRHSEASE-VSVCQEMMTELRSIILC--QDNIHPRRRRS 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	103/380 (27%)
		ANF_receptor	61..393	CDD:279440	93/344 (27%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	207/371 (56%)
		Lig_chan	555..829	CDD:278489	155/274 (57%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	103/387 (27%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	207/371 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.660